Revista Mexicana de Neurociencia

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>Revistas >Revista Mexicana de Neurociencia >Año 2006, No. 3

Robles L, Penalva de OAC, Vidal JE, Vasconcellos FA, Cedeno-Laurent F, Trujillo JR
Terapia antirretroviral en neurosida: prospectos de la vía olfatoria
Rev Mex Neuroci 2006; 7 (3)

Idioma: Español
Referencias bibliográficas: 46
Paginas: 231-239
Archivo PDF: 185.30 Kb.

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Las complicaciones neurológicas asociadas al virus de inmunodeficiencia humana tipo 1 (VIH-1) comprenden un espectro amplio, siendo el complejo demencial asociado a SIDA (CDS) una de las patologías más frecuentes. Las células de la microglia y astrocitos tienen un papel importante en la neuropatogénesis funcionando como reservorio viral y perpetuando la enfermedad. La limitada penetración de los medicamentos antirretrovirales al sistema nervioso central (SNC) impide la completa erradicación de los desórdenes neurológicos asociados al VIH/SIDA, por lo que nuevas vías de administración de estos medicamentos representan un área de investigación prometedora. En esta revisión describimos adelantos en materia del CDS, así como el papel de los antirretrovirales en neurosida; estudios clínicos de los Institutos Nacionales de Salud (NIH) y perspectivas a futuro en el área de terapéutica.

Palabras clave: SNC, CDS, antirretrovirales, VIH, SIDA, vía olfatoria.


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>Revistas >Revista Mexicana de Neurociencia >Año2006, No. 3
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