Entrar/Registro  
INICIO ENGLISH
 
Alergia, Asma e Inmunología Pediátricas
   
MENÚ

Contenido por año, Vol. y Num.

Índice de este artículo

Información General

Instrucciones para Autores

Mensajes al Editor

Directorio






>Revistas >Alergia, Asma e Inmunología Pediátricas >Año 2009, No. 1


Acuña-Martínez HG, Aguilar-Gómez S, Gaona-Jiménez LE, López-Pérez GT
Asociación de tres patologías inmunológicas: Deficiencia selectiva de IgA (transitoria), hipersensibilidad a la proteína de la leche y deficiencia de subclases de IgG2. Revisión de la literatura
Alerg Asma Inmunol Pediatr 2009; 18 (1)

Idioma: Español
Referencias bibliográficas: 68-69
Paginas: 10-15
Archivo PDF: 88.13 Kb.

[Texto completo - PDF]

RESUMEN

Deficiencia selectiva de IgA, la más frecuente. Presentación clínica: infecciones recurrentes respiratoria y digestiva. Se asocia: Deficiencia subclases de IgG (12%). Diagnóstico: niveles séricos IgA igual o menor de 7 mg/dL con niveles de IgG e IgM normales. Deficiencia de subclases IgG, disminución en 2 desviaciones estándar, con niveles normales totales de IgG. Hay 4 subtipos. La IgG2 (más frecuente) responsable en la respuesta a gérmenes encapsulados. Cursan con otitis media aguda, sinusitis, neumonía. Hipersensibilidad a las proteínas de la leche (HPL), es la alergia a alimentos más frecuente (1er año de vida). Compuestos de la leche de vaca son alergénicos: caseína, alfa-lactoglobulina, beta-lactoglobulina. Los órganos de choque: piel, aparato respiratorio y sistema gastrointestinal. Diagnóstico: estándar de oro, reto alimenticio controlado con placebo y doble ciego.


Palabras clave: Deficiencia selectiva de inmunoglobulina A, deficiencia de subclases de IgG e hipersensibilidad a la proteína de la leche de vaca.


REFERENCIAS

  1. Robertons PJ. Advances in the diagnosis of primary immunodeficiency disorders in childhood. Current Paediatrics 2001; 11: 149-157.

  2. García-Cruz, ML, Camacho R, Ortega-Martell JA, Berron-Pérez R, Espinosa-Rosales F, Hernández-Bautista V, Rojas-Garrido A. Registro de Inmunodeficiencias Primarias en pacientes mexicanos en una institución de tercer nivel: experiencia de 30 años. Alergia Asma e Inmunol Pediatric 2002; 11(2): 48-66.

  3. Bonilla FA, Bernstein L, Khan DA, Ballas ZK, Chinen J, Frank MM, Kobrynski LJ, Levinson AI, Mazer B, Nelson RP, Orange JS, Routes JM, Shearer WT, Sorensen RU. Practice parameter for the diagnosis and management of primary immunodeficiency. Ann Allergy Asthma Immunol 2005; 94: S1-S63.

  4. Notarangelo L, Casanova JL, Fischer A, Puck J, Rosen F, Seger R, Geha R. Primary immunodeficiency diseases: An update. J Allergy Clin Immunol 2004; 114: 677-87.

  5. Kowalczyk D, Mytar B, Zembala M. Cytokine production in transient hypogammaglobulinemia and isolated IgA deficiency. J Allergy Clin Immunol 1997; 100: 556-62.

  6. Quartier P. Déficits en IgA. Arch Pediatr 2001; 8: 629-33.

  7. Morimoto Y, Routes JM. Immunodeficiency overview. Prim Care Clin Office Pract 2008; 35: 159–173.

  8. Friman V, Nowrouziana FI, Adlerbertha I, Wolda AE. Increased frequency of intestinal Escherichia coli carrying genes for S. fimbriae and haemolysis in IgA-deficient individuals. Microbial Pathogen 2002; 32: 35-42.

  9. Sikora AG, Lee K. Otolaryngologic manifestations of immunodeficiency. Otolaryngol Clin N Am 2003; 36: 647-672.

  10. Cooper M, Pommering T, Koranyl K. Primary immunodeficiencies. Am Fam Physician 2003; 68: 2001-2011.

  11. Ballow M. Primary immunodeficiency disorders: Antibody deficiency. J Allergy Clin Immunol 2002; 109: 581-91.

  12. Cataldo F, Marino V, Botaro G. Greco P, Ventura A. Celiac disease and selective immunoglobulin a deficiency. J Pediatr 1997; 131: 306-308.

  13. Samolitis N, Hull C, Leiferman KM, Zone J. Dermatitis herpetiformis and partial IgA deficiency. J Am Acad Dermatol 2006; 54: S206-9.

  14. Braskett M, Roberts RL. Evaluation and treatment of children with primary immune deficiency in the emergency department. Clin Ped Emerg Med 2007; 8: 96-103.

  15. Azar A, Ballas Z. Evaluation of the adult with suspected immunodeficiency. Am J Med 2007; 120: 764-768.

  16. Cuninngham RC. Hematologic complications of primary immune deficiencies. Blood Rev 2002; 16: 61-64.

  17. Fazekas T, Wiesbauer P, Schroth B, Pötschger U, Gadner H, Heitger A. Selective IgA deficiency in children with recurrent parotitis of childhood. Pediatr Infect Dis J 2005; 24(5): 128-135.

  18. López-Mejía R, Martínez A, Del Pozo N, Fernández-Arqueroa M, Ferreira A, Urcelaya E, Fontán G, Núñez CC. Interleukin-6 gene variation in spanish patients with immunoglobulin-A deficiency. Human Immunology 2008; 69: 301-305.

  19. Rosen FS, Ralph JP, Wedgwood R, Eibl M, Fischer A, Aiuti F, Notarangelo L, Kishimoto T, Resnick I, Hammarstrom L, Seger R, Chapel H, Thompson RA, Cooper MD, Geha RS, Good RA, Waldmann AT. Report of a meeting held on 17 October 1996 at the Jenner Museum, Berkeley, Glos., UK. Primary Immunodeficiency Diseases 1997 Blackwell Science Ltd. Clin Exp Immunol 1998; 109: S1-28.

  20. Tormey V, Webster B. The immunocompromised patient: primary immunodeficiencies. Medic 2005; 33(3): 8-11.

  21. Lenhardta A, Plebanib A, Marchettia F, Gerarduzzia T, Nota T, Meinib A, Villanaccic V, Martelossia S, Ventura A. Role of human-tissue transglutaminase IgG and anti-gliadin IgG antibodies in the diagnosis of celiac disease in patients with selective immunoglobulin A deficiency. Digestive Liver Dis 2004; 36: 730-734.

  22. Rusconi F, Panisi C, Dellepiani RM, Cardinale F, Chini L, Martire B, Bonelli N, Felisate G, Prietogrande N. Pulmonary and sinus diseases in primary humoral immunodeficiencies with chronic productive cough. Arch Dis Chile 2003; 88: 1101-1105.

  23. Ruiz CJ. Inmunodeficiencias primarias. Enfoque y tratamiento iniciales. An Pediatr Contin 2003; 1(3): 131-8.

  24. Shkalim V, Monselise Y, Mosseri R, Finkelstein Y, Garty BZ. Recurrent parotitis in selective IgA deficiency. Pediatr Allergy Immunol 2004; 15: 281-283.

  25. Geha RS, Notarangelo LD, Casanova JL, Chapel H, Conley ME, Alain Fischer A. Hammarström L, Nonoyama S, Och H, Puck J, Roifman C, Seger R, Wedgwood J. Primary immunodeficiency diseases: An update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee. J Allergy Clin Immunol 2007; 120: 776-94.

  26. Notarangelo L, Casanova JL, Conley ME, Chapel H, Fischer A, Puck J, Roifman C, Seger R, Geha RS. Primary immunodeficiency diseases: An update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee Meeting in Budapest, 2005. J Allergy Clin Immunol 2006; 117: 883-96.

  27. Chandran PA, Asha Justus A, Balraj A, Job A, Kirubakaran C. Malignant otitis externa in an infant with selective IgA deficiency: a case report. Internat J Pediatric Otorhinolaryngol 2001; 60: 141-145.

  28. Horn J, Vojtech T, Bartonkoya D, Salzer J, Wartmatz K, Schlesier M, Hartmut PH, Grimbacher B. Anti-IgA antibodies in Common Variable Immunodeficiency (CVID): Diagnostic workup and therapeutic strategy. Clinical Immunology 2007; 122: 156-162.

  29. Vorechosky I, Zetterquist H, Paganelli R, Koskinen S, Webster D, Bjorkander J, Smith E, Hammarstrom L. Family and linkage study of selective IgA deficiency and common variable immunodeficiency. Clin Immunol and Immunopathol 1995; 77(2): 185-192.

  30. Peterson R, Kelly W, Good R. Ataxia-telangiectasia: its association with defective thymus, immunological deficiency disease and malignancy. Lancet 1964; 1: 1189-93.

  31. Bonilla FA, Geha RS. Update on primary immunodeficiency diseases. J Allergy Clin Immunol 2006; 117: S435-41.

  32. Castigli E, Wilson SA, Garibyan L, Rachid R, Bonilla F, Schneider L et al. TACI is mutant in common variable immunodeficiency and IgA deficiency. Nat Genet 2005; 37: 829-34.

  33. Salzer U, Chapel HM, Webster AD, Pan-Hammarstrom Q, Schmitt-Graeff A, Schlesier M et al. Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Nat Genet 2005; 37: 820-8.

  34. Oxelius VA, Laurell AB, Lindquist B, Golebioswsks H, Axelsson U, Bjorkander J, Hanson LA. IgG subclasses in selective IgA deficiency: Importance of IgG2 – IgA deficiency. N Engl J Med 1981; 304: 1476-1477.

  35. Lacombe C, Aucouturier P, Preud’homme JL. Selective IgG1 Deficiency. Clin Immunol and Immunopath 1997; 84(2): 194-201.

  36. Oxelius V, Laurell A, Lindquist B et al. IgG subclasses in selective IgA deficiency. N Engl J Med 1981; 304: 1476-7.

  37. Schur PH, Borel H, Gelfand EW, Alper CA, Rosen FS. Selective gamma-G globulin deficiencies in patients with recurrent pyogenic infections. New Engl J Med 1970; 283: 631–635.

  38. Shackelford P, Granoff D, Madassery J, Scott M, Nahm M. Clinical and immunologic characteristics of healthy children with subnormal serum concentrations of IgG2. Pediatr Res 1990; 27: 16-21.

  39. Soderstrom T, Soderstrom R, Avanzini A, Brandtzeg P, Karlson G, Hanson L. Immunoglobulin G subclass deficiencies. Int Arch Allergy Appl Immunol 1987; 82: 476-80.

  40. Depiero A, Kaminski DA, Halsey JF, Briles D, Burrows PD, Hostoffer RW. Immunologic compensation in a patient with a large IgH constant region deletion. J Allergy CIin Immunol 2001; 107: 1051-5.

  41. Stanley P, Corbo G, Cole P. Serum IgG subclasses in chronic and recurrent respiratory infections. Clin Exp Immunol 1984; 58: 703-8.

  42. Rezaei N, Aghamohammadia A, Davar Siadat S, Nejati M, Ahmadic H, Moina M, Pourpak Z, Kamali S, Norouzian D, Tabaraei B, Readb RC. Serum bactericidal antibody response to serogroup C polysaccharide meningococcal vaccination in children with primary antibody deficiencies. Vaccine 2007; 25: 5308–5314.

  43. Sukhai RN, Marsman WA. Recurrent parotitis and isolated IgG3 subclass deficiency. Eur J Pediatr 1999; 158: 684.

  44. Fox AT, Thomson M. Adverse reaction to cows milk. Paediatrics and Child Health 2007; 17(7): 288-294.

  45. Ortolani C, Pastorello EA. Food allergies and food intolerants. Best Pract Res Clin Gastroenterol 2006; 20(3): 467–483.

  46. Wilson J. Milk Intolerance: Lactose Intolerance and Cow’s Milk Protein Allergy. Newborn Infant Nursing Rev 2005; 5(4): 203-207.

  47. Sampson HA. Food allergy. JAMA 1997; 278: 888–894.

  48. Kocian J. Lactose intolerant. Int J Biochem 1988; 20(1): 1–5.

  49. Di Stefano M, Veneto G, Malservi S, Cecchetti L, Minguzzi L, Strocchi A, Corazza GR. Lactose malabsorption and intolerance and peak bone mass. Gastroenterol 2002; 122: 1793-1799.

  50. Bahna SL. Cow’s milk allergy versus cow milk intolerance. Ann Allergy Asthma Immunol 2002; 89(6 Suppl 1): 56-60.

  51. Host A. Clinical course of cow’s milk protein allergy and intolerance. Pediatr Allergy Immunol 1998; 9(Suppl 11): 48-52.

  52. Heine RG, Elsayed S, Hosking CS et al. Cow’s milk allergy in infancy. Curr Opin Allergy Clin Immunol 2002; 2: 217-25.

  53. Host A. Frequency of cow’s milk allergy in childhood. Ann Allergy Asthma Immunol 2002; 89(6 Suppl 1): 33-7.

  54. Host A. Cow’s milk protein allergy and intolerance in infancy. Pediatr Allergy Immunol 1994; 5: 5-36.

  55. Madsen C. Prevalence of food allergy: intolerance in Europe. Environm Toxicol Pharmacol 1997; 4: 163-167.

  56. Høst A, Halken S. A prospective study of cow milk allergy in Danish infants during the first 3 years of life. Allergy 1990; 45: 587.

  57. Halken S, Høst A, Hansen LG, Østerballe O. Effect of an allergy prevention programme on incidence of atopic symptoms in infancy. Allergy 1992; 47: 545.

  58. Wahn U. Aspects of nutritional management of food allergy. Pediatr Allergy Immunol 2001; 12: 75-77.

  59. Pressac M. Evaluation of assays of IgG antigen-specific antibodies. Immuno-analyse Biologie Spécialisée 2005; 99920: 32-38.

  60. Host A, Halken S, Jacobsen HT. Clinical course of cow’s milk protein allergy/intolerance and atopic diseases in childhood. Pediatr Allergy Immunol 2002; 13: 23-28.

  61. Wilson NW, Hamburger RN. Allergy to cow’s milk in the first year of life and its prevention. Ann Allergy 1988; 61: 323-328.

  62. Businco L, Bruno G, Giampietro PG. Soy protein for the prevention and treatment of children with cow-milk allergy. Am J Clin Nutr 1998; 68: 1447S-1452S.

  63. Hamburger RN, Casillas R, Johnson R et al. Long-term studies in prevention of food allergy: patterns of IgG anti–cow’s milk antibody responses. Ann Allergy 1987; 59: 175-178.

  64. Hill DJ, Firer MA, Shelton MJ et al. Manifestations of milk allergy in infancy. Clinical and immunological findings. J Pediatr 1986; 109: 270-276.

  65. Hill DJ, Ball G, Hosking CS et al. Gamma-interferon production in cow milk allergy. Allergy 1993; 48: 75-80.

  66. Isolauri E, Turjanmaa K. Combined skin prick and patch testing enhances identification of food allergy in infants with atopic dermatitis. J Allergy Clin Immunol 1996; 97: 9-15.

  67. Goldman AS, Anderson Jr DW, Sellers WA et al. Milk allergy I. Oral challenge with milk and isolated proteins in allergic children. Pediatrics 1963; 32: 425-443.

  68. Baker S, Cochran WJ, Greer FR et al. Hypoallergenic infant formulas. Pediatrics 2000; 106: 346-349.

  69. Ram FSF, Ducharme RM, Scarlett J. Cow’s milk protein avoidance and development of wheeze in children with a family history of atopy. Cochrane Database Syst Rev 2004: 4.



>Revistas >Alergia, Asma e Inmunología Pediátricas >Año2009, No. 1
 
 Buscar   Avanzada 


· Indice de Publicaciones 
· ligas de Interes 
       
Derechos Resevados 2007