2015, Number 3
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Acta Ortop Mex 2015; 29 (3)
Nontraumatic causes of bilateral avascular necrosis of the femoral head: link between hepatitis C and pegylated interferon
Gómez-Mont Landerreche JG, Gil-Orbezo F, Morales-Domínguez H, Navarrete-Álvarez M, Trueba-Davalillo C, Capuano-Tripp P
Language: Spanish
References: 30
Page: 172-175
PDF size: 133.34 Kb.
ABSTRACT
Background: Avascular necrosis of the femoral head is a frequent condition in patients with a history of trauma. The major pathologic causes include vascular diseases, malignancies, hypercoagulability states, long-term steroid treatment, and some patients have a history of hepatitis C infection treated with pegylated interferon and ribavirin. Upon studying the behavior of the hepatitis C virus, Seef, Foster and Poynard found a hypercoagulability state that causes interruption of retinacular blood flow to the femoral head, without an increased incidence of osteonecrosis in this patient group. Lauer states that such viral infections involve an autoimmune process and may result in transient vasculitides. Giampaolo, in 2005, reported the relationship between interferon use for multiple myeloma and other cancers and femoral avascular necrosis.
Material and methods: Cases with a diagnosis of bilateral osteonecrosis of the femoral head were assessed.
Results: Five patients were included, 4 females and one male, with a diagnosis of bilateral osteonecrosis of the femoral head. All of them had history of hepatitis C infection treated with pegylated interferon. The final diagnosis was proven by pathology after arthroplasty. A literature review was made of articles on the relationship between this condition and interferon use in patients with hepatitis C infection.
Conclusions: Finding out the relationship between viral diseases such as hepatitis B and C infection and hypercoagulability states, autoimmune processes leading to transient vasculitides and the use of pegylated interferon 2B, will help us discover new nontraumatic causes associated with this condition.
REFERENCES
Guerra JJ, Steinberg ME: Distinguishing transient osteoporosis from avascular necrosis of the hip. J Bone Joint Surg Am. 1995; 77(4): 616-24.
Mont MA, Hungerford DS: Non-traumatic avascular necrosis of the femoral head. J Bone Joint Surg Am. 1995; 77(3): 459-74.
Sinha P, Kim A, Freeman LM: Symmetric avascular necrosis of the shoulders and hips in sickle cell disease. Clin Nucl Med. 1999; 24(6): 445.
Collier BD, Carrera GF, Johnson RP, Isitman AT, Hellman RS, Knobel J, et al: Detection of femoral head avascular necrosis in adults by SPECT. J Nucl Med. 1985; 26(9): 979-87.
Talamo G, Angtuaco E, Walker RC, Dong L, Miceli MH, Zangari M, et al: Avascular necrosis of femoral and/or humeral heads in multiple myeloma: results of a prospective study of patients treated with dexamethasone-based regimens and high-dose chemotherapy. J Clin Oncol. 2005; 23(22): 5217-23.
Scheiber C, Meyer ME, Dumitresco B, Demangeat JL, Schneegans O, Javier RM, et al: The pitfalls of planar three-phase bone scintigraphy in nontraumatic hip avascular osteonecrosis. Clin Nucl Med. 1999; 24(7): 488-94.
Scully SP, Aaron RK, Urbaniak JR: Survival analysis of hips treated with core decompression or vascularized fibular grafting because of avascular necrosis. J Bone Joint Surg Am. 1998; 80(9): 1270-5.
Shimizu K, Moriya H, Akita T, Sakamoto M, Suguro T: Prediction of collapse with magnetic resonance imaging of avascular necrosis of the femoral head. J Bone Joint Surg Am. 1994; 76(2): 215-23.
Liu YF, Chen WM, Lin YF, Yang RC, Lin MW, Li LH, et al: Type II collagen gene variants and inherited osteonecrosis of the femoral head. N Engl J Med. 2005; 352(22): 2294-301.
Al Ghumlas AK, Abdel-Gader AG, Al Faleh FZ: Natural anticoagulants and fibrinolytic activity following interferon therapy in chronic viral hepatitis. Blood Coagul Fibrinolysis. 2008; 19(4): 263-7.
Borg FA, Isenberg DA: Syndromes and complications of interferon therapy. Curr Opin Rheumatol. 2007; 19(1): 61-6.
Dudley FJ, Scheuer PJ, Sherlock S: Natural history of hepatitis-associated antigen positive chronic liver disease. Lancet. 1972; 2(7792): 1388-93.
Mankin HJ: Nontraumatic necrosis of bone (osteonecrosis). N Engl J Med. 1992; 326(22): 1473-9.
Hasan SS, Romeo AA: Nontraumatic osteonecrosis of the humeral head. J Shoulder Elbow Surg. 2002; 11(3): 281-98.
Assouline-Dayan Y, Chang C, Greenspan A, Shoenfeld Y, Gershwin ME: Pathogenesis and natural history of osteonecrosis. Semin Arthritis Rheum. 2002; 32(2): 94-124.
Hattrup SJ, Cofield RH: Osteonecrosis of the humeral head: relationship of disease stage, extent, and cause to natural history. J Shoulder Elbow Surg. 1999; 8(6): 559-64.
Korompilias AV, Ortel TL, Urbaniak JR: Coagulation abnormalities in patients with hip osteonecrosis. Orthop Clin North Am. 2004; 35(3): 265-71.
Glueck CJ, Freiberg RA, Fontaine RN, Tracy T, Wang P: Hypofibrinolysis, thrombophilia, osteonecrosis. Clin Orthop Relat Res. 2001; (386): 19-33.
Vento S, Di Perri G, Garofano T, Cosco L, Concia E, Ferraro T, et al: Hazards of interferon therapy for HBV-seronegative chronic hepatitis. Lancet. 1989; 2(8668): 926.
Kassianides C, Di Bisceglie AM, Hoofnagle JH: Alpha interferon therapy in patients with descompensated chronic type B hepatitis. In: Zuckerman AJ, editor. Viral hepatitis and liver disease. Nueva York: Alan R. Liss; 1988: 840-3.
Ruiz-Moreno M, Carreño V, Rúa MJ, Cotonat T, Serrano B, Santos M, et al: Increase in triglycerides during alpha-interferon treatment of chronic viral hepatitis. J Hepatol. 1992; 16(3): 384.
Subdirección General de Prestaciones y Evaluación de Tecnologías Sanitarias. Tratamiento con interferón en las hepatitis crónicas. Madrid: Dirección General de Aseguramiento y Planificación Sanitaria, Ministerio de Sanidad y Consumo.
Aaron RK: Osteonecrosis: etiology, pathophysiology, and diagnosis. In: Callahan JJ, Rosenberg AG, Rubash HE. The adult hip. Philadelphia, Pa: Lippincott-Raven Publishers; 1998: 451-66.
Ficat RP: Idiopathic bone necrosis of the femoral head. Early diagnosis and treatment. J Bone Joint Surg Br. 1985; 67(1): 3-9.
Seeff LB, Miller RN, Rabkin CS, Buskell-Bales Z, Straley-Eason KD, Smoak BL, et al: 45-Year follow-up of hepatitis C virus infection in healthy young adults. Ann Intern Med. 2000; 132(2): 105-11.
Foster GR, Goldin RD, Thomas HC: Chronic hepatitis C virus infection causes a significant reduction in quality of life in the absence of cirrhosis. Hepatology. 1998; 27(1): 209-12.
Poynard T, Bedossa P, Opolon P: Natural history of liver fibrosis progression in patients with chronic hepatitis C. Lancet. 1997; 349(9055): 825-32.
Lauer GM, Walker BD: Hepatitis C virus infection. N Engl J Med. 2001; 345(1): 41-52.
Sinha P, Kim A, Freeman LM: Symmetric avascular necrosis of the shoulders and hips in sickle cell disease. Clin Nucl Med. 1999; 24(6): 445.
Adverse Drug Reactions Advisory Committee: Avascular necrosis with interferon alfa-2b in CML. Australian Adverse Drug Reactions Bulletin. 2005; 24(2): 6.