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>Journals >Revista Alergia México >Year 2016, Issue 3


González-Díaz SN, Arias-Cruz A, Rivero-Arias DM, Partida-Ortega AB, Elizondo-Villarreal B, Ibarra-Chávez JA, Ramos-Valencia L, Monge-Ortega OP, Macouzet-Sánchez C, Salinas-Díaz MR
Cross-reactivity in allergic fungal sinusitis. Case report
Revista Alergia México 2016; 63 (3)

Language: Español
References: 11
Page: 316-319
PDF: 484.30 Kb.

[Full text - PDF]

ABSTRACT

Background: The presence of allergic mucin in allergic fungal sinusitis (AFS) is a manifestation that identifies it as a hypersensitivity process. AFS has a phenomenon of cross-reactivity to IgEbound proteins having at least two shared epitopes.
Case report: A 13-year-old male with nasal obstructive symptoms of three years of evolution. An obstructive mass was identified in the sinuses through physical examination and CT. In endoscopic surgery, the left nostril polyp was identified with the macroscopic appearance of allergic mucin; the polyp was resected. Final histopathological examination using periodic acid-Schiff and Grocott’s methenamine silver staining indicated Aspergillus. Two weeks after surgery, percutaneous tests showed sensitization to Alternaria, Helminthosporium sativum, and Deramatophagoides farianae with negativity to Aspergillus fumigatus.
Conclusions: The absence of significant titers of specific IgE antibodies to Aspergillus fumigatus was the evidence that the hypersensitivity response was triggered by a pathogen other than that isolated in histopathological study, which coupled with positive tests for other fungi may be explained by the cross-reactivity phenomenon in a phenomenon of likely hypersensitivity.


Key words: Allergic fungal sinusitis, Rhinosinusitis, Aspergillus, Corticosteroids.





>Journals >Revista Alergia México >Year 2016, Issue 3
 
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