Ulises MIU

Idioma: Español
Referencias bibliográficas: 12
Paginas: 403-406
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RESUMEN

lupus es una enfermedad autoinmunitaria mediada por linfocitos B. Como en la mayor parte de las enfermedades autoinmunitarias, en la aparición del lupus se han implicado factores genéticos, hormonales y ambientales. Estudios serológicos, moleculares y experimentales sugieren una asociación entre el virus de Epstein-Barr y el lupus. Sin embargo, la relación entre el virus de Epstein-Barr y el lupus es materia de controversia.

REFERENCIAS (EN ESTE ARTÍCULO)

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2. James JA, Kaufman KM, Farris AD, Taylor-A, et al. An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus. J Clin Invest 1997; 100: 3019-3026. doi. 10.1172/JCI119856.

3. James JA, Neas BR, Hall T, Bruner GRK, et al. Systemic lupus erythematosus in adults is associated with previous Epstein-Barr virus exposure. Arthritis Rheum 2001; 44: 1122-6. doi. 10.1002/1529-0131(200105)44:5<1122::AIDANR193> 3.0.CO;2-D.

4. Mercado U, Díaz-Molina R, Acosta H. Epstein-Barr virus and lupus. Curr Topics Virol 2010; 8: 59-61.

5. Li ZX, Zeng S, Wu HX, Zhou Y. The risk of systemic lupus erythematosus associated with Epstein-Barr virus infection: a systematic review and meta-analysis. Clin Exp Med 2019;19:23-36. doi. 10.1007/s10238-018-0535-0.

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7. Poole BD, Gross T, Maier S, Harley JB, et al. Lupus like autoantibody development in rabbits and mice after immunization with EBNA-1 fragments. J Autoimmun 2008; 31: 362-371. doi. 10.1016/j.jaut.2008.08.007.

8. Arbuckle MR, Gross T, Scofield RH, Hinshaw LB, et al. Lupus humoral autoimmunity induced in a primate model by short peptide immunization. J Invest Med 1998; 46: 58-65.

9. Sundar K, Jacques S, Gottlieb P, Villars S, et al. Expression of the Epstein-Barr virus nuclear antigen -1 (EBNA-1) in the mouse can elicit the production of anti-dsDNA and anti-SM antibodies. J Autoimmunity 2004; 23: 127-40.

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11. Tsai YT, Chiang BL, Kao YF, Hsieh KH. Detection of Epstein-Barr virus and cytomegalovirus genoma in white blood cells from patients with juvenile rheumatoid arthritis and childhood systemic lupus erythematosus. Int Arch Allergy Immunol 1995; 106: 235-240. doi. 10.1159/000236848.

12. Mason LJ, Thimothy LM, Isenberg DA, Kalsi JK. Immunization with a peptide of Sm B/B results in limited epitope spreading but not autoimmune disease. J Immunol 1999; 162: 5099-105.