López PAG, de la Cruz PA, Reyes TJL, Díaz CC

Idioma: Español
Referencias bibliográficas: 107
Paginas: 48-60
Archivo PDF: 351.57 Kb.

RESUMEN

La metilación en la posición N6 de la adenosina (m6A) es la modificación más frecuente encontrada en el RNA mensajero (mRNA) en eucariotes. Es un mecanismo conservado de regulación postranscripcional de la expresión génica que regula el destino y función del mRNA. En esta revisión, se analizan y resumen los avances más recientes sobre m6A, así como su papel en la regulación genética. La modificación reversible de m6A en los mRNA representa un marcador epigenético novedoso con papeles regulatorios en procesos biológicos fundamentales.

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