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2020, Número 2

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Revista Cubana de Obstetricia y Ginecología 2020; 46 (2)


Tumor de células de la granulosa

Redondo VA, Azcona SL, Frías SZ, Gutiérrez DÁ, Jiménez GJ, Rodriguez JI, Polo VA, Cabezas PMN, Pantoja GM

Idioma: Español
Referencias bibliográficas: 39
Paginas: 1-17
Archivo PDF: 474.58 Kb.


RESUMEN

Introducción: El tumor de células de la granulosa representa 2-5 % de las neoplasias de ovario. Aunque su clínica viene dada por el aumento de estradiol secretado por el tumor, en muchas ocasiones se manifiesta con clínica muy inespecífica. El diagnóstico de sospecha se basa en la combinación de la sintomatología con las pruebas de imagen compatibles y la determinación de inhibina. Su manejo resulta controvertido. Como abordaje quirúrgico estándar se realiza una resección completa que incluye histerectomía abdominal total, salpingooforectomía bilateral y estratificación quirúrgica. Se ha demostrado que el estadio de la enfermedad es el factor pronóstico más importante en términos de supervivencia.
Objetivos: Presentar una serie de casos clínicos con tumor de células de la granulosa para determinar las diversas formas de presentación, y establecer protocolos de diagnóstico y tratamiento unificados, a partir de una revisión bibliográfica exhaustiva.
Métodos: Se realiza una búsqueda en las bases de datos de Medline vía PubMed con las palabras claves obtenidas del MeSH: "granulosa cell tumour; stromal ovarian tumor; ovary carcinoma", y se seleccionan con preferencia los trabajos referidos al diagnóstico, tratamiento y pronóstico de esta neoplasia.
Presentación de caso: Presentamos una serie de casos de tumores de células de la granulosa que fueron diagnosticados y tratados en nuestro hospital.
Conclusiones: Los tumores de células de la granulosa son tumores con bajo grado de malignidad y diseminación preferentemente local. Su pronóstico es bastante bueno, con una tasa de supervivencia de 10 años en más del 80 % de los casos.


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