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2023, Número 1

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salud publica mex 2023; 65 (1)


Cocirculación y reemplazo de variantes de SARS-CoV-2 en espacios hacinados y poblaciones marginadas en la frontera México-EUA

Chaillon A, Bojorquez I, Sepulveda J, Harvey-Vera AY, Rangel MG, Skaathun B, Mehta SR, Ignacio C, Porrachia M, Smith DM, Strathdee SA
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Idioma: Ingles.
Referencias bibliográficas: 26
Paginas: 10-18
Archivo PDF: 562.88 Kb.


PALABRAS CLAVE

SARS-CoV-2, linajes, recombinación genética, usuarios de drogas, migrantes.

RESUMEN

Objetivo. Investigar los linajes circulantes y variantes recombinantes de SARS-CoV-2 en migrantes en albergues y usuarios de drogas inyectables (UDI). Material y métodos. Se combinaron datos de dos estudios con poblaciones marginadas (migrantes en albergues y UDI) en Tijuana, México. Se identificaron variantes de SARS-CoV-2 en exudado nasal y se compararon con genomas disponibles públicamente de muestras de México y California. Resultados. Ocho de 10 linajes identificados se detectaron principalmente en Norte y Centro América. Las discrepancias entre migrantes y UDI se pueden explicar por la emergencia temporal y la corta duración de la mayoría de estos linajes en la región. Conclusión. Los resultados ilustran la estructura temporo-espacial de la dispersión de linajes de SARS-CoV-2, y la circulación posible de linajes múltiples en poblaciones en riesgo con contactos sociales estrechos. Estas condiciones generan el potencial de recombinación en la frontera California-Baja California.


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