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2021, Número 3

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Rev Cubana Plant Med 2021; 26 (3)


Efecto hepatoprotector de hojas de Morus nigra L. sobre daño hepático en ratas inducido por acetaminofeno

Gonzales CEG, Arce RFA, Magaño CMN, Ramírez RSA, Paz-Aliaga A

Idioma: Ingles.
Referencias bibliográficas: 52
Paginas:
Archivo PDF: 467.58 Kb.


RESUMEN

Introducción: El acetaminofeno es uno de los fármacos analgésicos y antipiréticos más utilizados. Se caracteriza por los efectos hepatotóxicos que produce luego de una administración prolongada por la formación excesiva de N-acetil-p-benzoquinoneimina intermedia, producto del metabolismo en fase I. Las hojas de Morus nigra L. presentan actividad terapéutica debido a su composición química y capacidad antioxidante.
Objetivos: Evaluar el efecto hepatoprotector del extracto hidroalcohólico de Morus nigra L. en ratas con daño hepático inducido por acetaminofeno.
Métodos: Veinte ratas (Rattus norvergicus albinus) se dividieron en cuatro grupos: control, acetaminofeno (250 mg/kg) como grupo control de hepatotoxicidad, acetaminofeno + silimarina (100 mg/kg) y acetaminofeno + Morus nigra L. (250 mg/kg). Las enzimas de función hepática ALT y AST fueron medidas los días 1, 6, 12 y 21. Además, se realizó un estudio histopatológico en secciones de hígado.
Resultados: El acetaminofeno aumentó los niveles de ALT y AST, lo cuales se mantuvieron elevados luego de la administración de agua destilada como placebo hasta el día 21. La silimarina y el extracto de hojas Morus nigra L disminuyeron los niveles de ALT y AST hasta niveles similares del control (basal).
Conclusiones: Los resultados del presente estudio demostraron que la administración de Morus nigra L mejora la lesión hepática producida por el acetaminofeno con efecto significativamente similar al de la silimarina.


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