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2023, Número 3

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Rev Educ Bioquimica 2023; 42 (3)


La citocina TGF-β en la salud y la enfermedad

Síntesis, secreción y activación de la citocina TGF-β en la salud y la enfermedad

Toledo PD, Coquis BDA, Sosa GM, Macías SM

Idioma: Español
Referencias bibliográficas: 38
Paginas: 141-151
Archivo PDF: 679.23 Kb.


RESUMEN

El TGF-β es una citocina sintetizada y secretada en forma latente, formando un complejo con LAP, un péptido asociado a la latencia. El TGF-β puede ser secretado en una forma soluble o empaquetado en vesículas extracelulares. Existen diferentes señales que inducen su expresión y distintos mecanismos que conducen a su activación al liberarlo del complejo con LAP para iniciar su señalización.


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