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2024, Número 1

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Salud Mental 2024; 47 (1)


Circulating sex hormones in women with severe anxiety during pregnancy

Leff-Gelman P, Camacho-Arroyo I, Camacho PRT, Coronel CFM, Gaspard CAV, Jiménez ALE, Solares-Bravo M, Flores-Ramos M

Idioma: Ingles.
Referencias bibliográficas: 68
Paginas: 3-12
Archivo PDF: 278.68 Kb.


RESUMEN

Introducción. La ansiedad, el estado de ánimo y el estrés están regulados por diversos esteroides sexuales. Existe poca información sobre el papel que juegan estos esteroides en mujeres embarazadas con niveles elevados de ansiedad. Objetivo. Determinar los niveles séricos de hormonas sexuales en mujeres embarazadas con altos índices de síntomas de ansiedad con respecto a mujeres gestantes sanas. Método. Determinación de la intensidad de síntomas ansiosos empleando la escala de Hamilton de Ansiedad (HAM-A) en 141 mujeres embarazadas en el tercer trimestre de gestación. Cuantificación de los niveles séricos de estradiol (E2), progesterona (P4) y testosterona (T) por inmunoensayo estándar. Aplicación de las correlaciones de Pearson para detectar asociaciones entre parámetros clínicos y valores hormonales entre los grupos de estudio. Resultados. Las mujeres con ansiedad severa (ANX; n = 101; HAM-A ≥ 25) mostraron niveles séricos más altos de E2 y T (p ‹.001), así como niveles más bajos de P4 (p ‹ .001) en relación con el grupo control (CTRL, n = 40, HAM-A ‹ 7). Se detectó una disminución significativa en el índice P4:E2 en el grupo de ANX (p ‹ .001) y se observaron correlaciones negativas y positivas entre los puntajes elevados de ansiedad con los niveles circulantes de P4 (p = .02), en la taza P4:E2 (p = .04) y en los niveles séricos de T (p = .001) respectivamente, al ajustar nuestros datos con variables confusoras. Discusión y conclusión. Los niveles circulantes de los esteroides sexuales se encontraron alterados en mujeres con ansiedad severa.


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