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Coordinación General de Investigación de la Facultad de Salud Pública y Nutrición y la Dirección General de Sistemas e Informática de la Universidad Autónoma de Nuevo León

2024, Número 2

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Rev Salud Publica Nutr 2024; 23 (2)


Una revisión de estudios experimentales sobre hepatotoxicidad relacionada a la exposición por acrilamida

Martínez-Ortiz MG, García-Palafox LC, Martínez-Toto Á, Ruíz-Ramos R, Sánchez-Otero MG

Idioma: Español
Referencias bibliográficas: 49
Paginas: 35-46
Archivo PDF: 440.80 Kb.


RESUMEN

Introducción: La acrilamida es un compuesto tóxico que puede formarse en alimentos preparados a altas temperaturas, en exposición crónica provoca neurotoxicidad, genotoxicidad, y puede ser carcinógena. El hígado es el principal encargado de su metabolismo, la acrilamida y sus metabolitos pueden producir daños e inflamación crónica hepática que pueden desencadenar patologías graves.
Objetivo: Analizar la información más reciente con relación a la hepatotoxicidad asociada a la ingesta de acrilamida.
Material y Método: Se realizó una revisión hemerográfica en PubMed, ScienceDirect y Google Académico, utilizando términos MeSH: liver, toxicity, acrylamide, oxidative stress, Wistar Rat y Booleanos: “and”, “or”, “not” considerando artículos a partir del 2018, seleccionando los que describieran en su contenido datos relacionados las palabras clave.
Resultados: La hepatotoxicidad por exposición a acrilamida está relacionada a alteraciones de biomarcadores de estrés oxidativo, cambios en metabolómica y en procesos de autofagia, activación del inflamasoma, y modificaciones estereológicas e histológicas.
Conclusión: La información actualizada demuestra que a la hepatotoxicidad asociada a acrilamida le subyacen diversos mecanismos celulares en los que generalmente está involucrado el estrés oxidativo, por ello el abordaje de estrategias para entender y disminuir el impacto de la exposición debe considerar dichos aspectos.


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