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TIP Revista Especializada en Ciencias Químico-Biológicas

2023, Número 1

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TIP Rev Esp Cienc Quim Biol 2023; 26 (1)


El AB“Y” de la fosforilación de tirosinas en bacterias: descripción de las enzimas implicadas y su impacto en la fisiología procarionte

Andrade Á, Alonso ÓM, Tavares-Carreón F

Idioma: Español
Referencias bibliográficas: 76
Paginas: 1-12
Archivo PDF: 417.31 Kb.


RESUMEN

La fosforilación de proteínas en residuos de serina, treonina y tirosina representa un paradigma central de la señalización celular. No obstante, en procariontes esta modificación postraduccional (MPT) fue desestimada durante varias décadas. Diversos estudios fosfoproteómicos bacterianos, así como la identificación y caracterización exhaustiva de las enzimas responsables de la fosforilación de proteínas en estos organismos ha derivado en una nueva visión del alcance regulatorio asociado a esta MPT. En particular, esta revisión se centra en la fosforilación en residuos de tirosina, las enzimas cinasas y fosfatasas implicadas en este proceso, su mecanismo de acción y el impacto de su actividad sobre la fisiología bacteriana.


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