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Acta Pediatr Mex 2024; 45 (S3)


Cambios en los islotes pancreáticos maternos después de la lactancia

Canul MG, Riverón NL, Pastén HK, Morales CP, García VF, Fernández MC

Idioma: Español
Referencias bibliográficas: 27
Paginas: S20-S26
Archivo PDF: 696.70 Kb.


RESUMEN

Los islotes pancreáticos se adaptan ante diferentes demandas metabólicas y cambios hormonales a través de la modificación en su tamaño y secreción hormonal. Existe poca información acerca de los islotes pancreáticos maternos y el metabolismo de la glucosa materna después de la lactancia. Nuestro equipo de trabajo examinó la morfología de los islotes maternos y la homeostasis de la glucosa después de la lactancia en ratones de la cepa C57BL/6. Después de la lactancia, se encontró un incremento en el tamaño de los islotes y la proliferación de los islotes materno. También se modificó la secreción de insulina, tolerancia a la glucosa y sensibilidad a la insulina. Estos resultados abren un nuevo campo de oportunidades para la identificación de moléculas y mecanismos que participen en estos procesos y que ayuden en el desarrollo de estrategias para combatir la diabetes.


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