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Organo Oficial de la Sociedad Mexicana de Urología

2025, Número 5

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Rev Mex Urol 2025; 85 (5)


Neoplasias sanguíneas con afectación peneana como primera manifestación

Utiel AA, Botto LSM, Ortiz SP, Palau RM, González DD, Ferrer GR, Cuenca RMD, Bermell ML, Planelles GJ

Idioma: Español
Referencias bibliográficas: 34
Paginas: 1-12
Archivo PDF: 266.61 Kb.


RESUMEN

Descripción de los casos clínicos: se presentan los casos de dos neoplasias hematológicas frecuentes, un linfoma B difuso de células grandes (LBDCG) y una recidiva de leucemia aguda mieloblástica (LAM), pero con una presentación clínica inicial extremadamente rara como es la afectación peneana. En ambos casos el tratamiento consistió en quimioterapia añadiendo además radioterapia en el caso de la LAM, sin precisar de cirugía en su manejo.
Relevancia: se realiza una revisión de la bibliografía de los casos publicados hasta la fecha, encontrando publicados únicamente veinte casos de LBDCG del pene y 5 casos afectación extramedular de LAM en el pene.
Implicaciones clínicas: el conocimiento de la afectación peneana por neoplasias sanguíneas es importante por su alta respuesta al tratamiento médico y por la posibilidad de prescindir de intervenciones radicales o mutilantes.
Conclusiones: la biopsia de una lesión peneana debe realizarse en todos los casos antes de plantearse un tratamiento local.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Ibarz Servio L, Arzoz Fábregas M, RuizDomínguez JM, Batlle Massana M, Mate SanzJL, Saladié Roig JM. [Primary lymphoma ofpenis]. Actas Urologicas Espanolas. 2009;33(7):826–829. https://doi.org/10.1016/s0210-4806(09)74238-x.

  2. Oomura J, Ookita K, Takenaka M, Yamada S.[Primary reticulosarcoma of the penis. Report ofa case]. Hinyokika Kiyo. Acta Urologica Japonica.1962;8: 536–542.

  3. Yu T, Zou L, Wang Y, Luo C, Yu L. PrimaryDiffuse Large B-Cell Lymphoma of the Penis:A Case and Literature Review. OncoTargetsand Therapy. 2023;16: 631–638. https://doi.org/10.2147/OTT.S408195.

  4. D’Arena G, Guariglia R, Villani O, MartorelliMC, Pietrantuono G, Mansueto G, et al. Anurologic face of chronic lymphocytic leukemia:sequential prostatic and penis localization.Mediterranean Journal of Hematology andInfectious Diseases. 2013;5(1): e2013008.https://doi.org/10.4084/MJHID.2013.008.

  5. Broseta E, Budía A, Burgués JP, Luján S. Tumorde pene. In: Urología práctica. 5th edn España:Elsevier; 2021.

  6. Cho-Vega JH, Medeiros LJ, Prieto VG, VegaF. Leukemia cutis. American Journal of ClinicalPathology. 2008;129(1): 130–142. https://doi.org/10.1309/WYACYWF6NGM3WBRT.

  7. GONG Z, ZHANG Y, CHU H, LIAN P, ZHANGL, SUN P, et al. Priapism as the initial symptomof primary penile lymphoma: A case report.Oncology Letters. 2014;8(5): 1929–1932.https://doi.org/10.3892/ol.2014.2488.

  8. Ponniah A, Brown CT, Taylor P. Priapismsecondary to leukemia: effective managementwith prompt leukapheresis. InternationalJournal of Urology: Official Journal of theJapanese Urological Association. 2004;11(9):809–810. https://doi.org/10.1111/j.1442-2042.2004.00872.x.

  9. Suttorp M, Sembill S, Kalwak K, Metzler M,Millot F. Priapism at Diagnosis of PediatricChronic Myeloid Leukemia: Data Derived froma Large Cohort of Children and Teenagers anda Narrative Review on Priapism Management.Journal of Clinical Medicine. 2023;12(14): 4776.https://doi.org/10.3390/jcm12144776.

  10. Bintoro SUY, Romadhon PZ, Suryantoro SD,Aminy RZ, Windradi C, Widiyastuti KN. CaseReport: Priapism as The Clinical PresentingFeature of Chronic Myeloid Leukemia: CaseReport and 20-Year Literature Review.F1000Research. 2021;10: 571. https://doi.org/10.12688/f1000research.53365.2.

  11. Chiang KH, Chang PY, Lee SK, Yen PS, LingCM, Lin CC, et al. MR findings of penilelymphoma. The British Journal of Radiology.2006;79(942): 526–528. https://doi.org/10.1259/bjr/55555394.

  12. el-Sharkawi A, Murphy J. Primary penilelymphoma: the case for combined modalitytherapy. Clinical Oncology (Royal Collegeof Radiologists (Great Britain)). 1996;8(5):334–335. https://doi.org/10.1016/s0936-6555(05)80726-5.

  13. Chu L, Mao W, Curran Vikramsingh K, Liu X,Qiu HM, Zheng JH, et al. Primary malignantlymphoma of the glans penis: a rare case reportand review of the literature. Asian Journal ofAndrology. 2013;15(4): 571–572. https://doi.org/10.1038/aja.2013.21.

  14. Hashine K, Akiyama M, Sumiyoshi Y.Primary Diffuse Large Cell Lymphomaof the Penis. International Journal ofUrology. 1994;1(2): 189–190. https://doi.org/10.1111/j.1442-2042.1994.tb00035.x.

  15. Beal K, Mears JG. Short report: penilelymphoma following local injections forerectile dysfunction. Leukemia & Lymphoma.2001;42(1–2): 247–249. https://doi.org/10.3109/10428190109097700.

  16. Kuwahara Y, Kubota Y, Hibi H, Yanaoka Y,Okishio N, Hoshinaga K, et al. [Malignantlymphoma of the penis: report of two cases].Hinyokika Kiyo. Acta Urologica Japonica.1997;43(5): 371–374.

  17. Fenech M, Pisani D, Camilleri DJ. Primaryhigh-grade diffuse large B-cell lymphoma of theglans penis. BMJ Case Reports CP. 2021;14(11):e243844. https://doi.org/10.1136/bcr-2021-243844.

  18. Marks D, Crosthwaite A, Varigos G, Ellis D,Morstyn G. Therapy of primary diffuse largecell lymphoma of the penis with preservationof function. The Journal of Urology. 1988;139(5):1057–1058. https://doi.org/10.1016/s0022-5347(17)42771-6.

  19. Arena F, di Stefano C, Peracchia G, BarbieriA, Cortellini P. Primary Lymphoma of thePenis: Diagnosis and Treatment. EuropeanUrology. 2001;39(2): 232–235. https://doi.org/10.1159/000052441.

  20. Delicato G, Baffigo G, Bianchi D, Farullo G,Signore S, Tartaglia E, et al. ConservativeTherapy in Two Cases of Non-HodgkinLymphoma of the Penis: Case Reports WithReview of the Literature. World Journal ofOncology. 2012;3(1): 37–38. https://doi.org/10.4021/wjon438w.

  21. Stamatiou K, Pierris N. Lymphoma Presentingas Cancer of the Glans Penis: A Case Report.Case Reports in Pathology. 2012;2012: 948352.https://doi.org/10.1155/2012/948352.

  22. Karki K, Mohsin R, Mubarak M, HashmiA. Primary Non-Hodgkin’s Lymphoma ofPenis Masquerading as a Non-Healing Ulcerin the Penile Shaft. Nephro-urology Monthly.2013;5(3): 840–842. https://doi.org/10.5812/numonthly.6885.

  23. Diao L, Yang S, Shang P, Hou Z. Report of penislymphoma and review of the literature. AsianJournal of Surgery. 2022;45(11): 2528–2529.https://doi.org/10.1016/j.asjsur.2022.05.136.

  24. Kim HY, Oh SY, Lee S, Lee DM, Kim SH, KwonHC, et al. Primary Penile Diffuse Large B CellLymphoma Treated by Local Excision Followedby Rituximab-Containing Chemotherapy. ActaHaematologica. 2008;120(3): 150–152. https://doi.org/10.1159/000178146.

  25. Hamamoto S, Tozawa K, Nishio H, KawaiN, Kohri K. Successful treatment of primarymalignant lymphoma of the penis by organpreservingrituximab-containing chemotherapy.International Journal of Clinical Oncology.2012;17(2): 181–184. https://doi.org/10.1007/s10147-011-0273-8.

  26. Karunanithi S, Sharma P, Naswa N,Soundararajan R, Mohapatra T, Malhotra A, etal. Primary penile lymphoma: the use of PET-CTfor accurate staging and response monitoring.Diagnostic and Interventional Radiology (Ankara,Turkey). 2013;19(2): 130–133. https://doi.org/10.4261/1305-3825.DIR.6253-12.1.

  27. Guo Y, Bai RJ, Gao S. FDG PET/CT detectsmalignant lymphoma invading the penis.Clinical Nuclear Medicine. 2011;36(12):e204-206. https://doi.org/10.1097/RLU.0b013e31823361e1.

  28. Wang GC, Peng B, Zheng JH. Primary penilemalignant lymphoma: report of a rare case.Canadian Urological Association Journal = JournalDe l’Association Des Urologues Du Canada.2012;6(6): E277-279. https://doi.org/10.5489/cuaj.11299.

  29. Murn J, Alibert O, Wu N, Tendil S, Gidrol X.Prostaglandin E2 regulates B cell proliferationthrough a candidate tumor suppressor,Ptger4. The Journal of Experimental Medicine.2008;205(13): 3091–3103. https://doi.org/10.1084/jem.20081163.

  30. Hsiao LT, Yang CF, Tzeng CH. Penis: a‘sanctuary’ site of extramedullary leukemiarelapse. International Journal of Hematology.2009;90(2): 125–126. https://doi.org/10.1007/s12185-009-0369-3.

  31. Begun FP, Derus J, Toorkey B, AlmagroU. Leukemia of the penis. The Journal ofUrology. 1989;142(1): 123–124. https://doi.org/10.1016/s0022-5347(17)38681-0.

  32. Aizawa S, Osawa T, Kikuchi H, MatsumotoR, Abe T, Shiratori S, et al. [LeukemiaRelapse as Granulocytic Sarcoma Beginningwith Penile Localization : A Case Report].Hinyokika Kiyo. Acta Urologica Japonica.2022;68(2): 63–66. https://doi.org/10.14989/ActaUrolJap_68_2_63.

  33. Toh JJH, Chia HY, Heng YK. Penile Ulcerdue to Leukemia Cutis-A Rare DiagnosisNot to Be Missed. The American Journal of Dermatopathology. 2020;42(7): 524–525. https://doi.org/10.1097/DAD.0000000000001604.

  34. Martin-Babau J, Tempescul A, Moreau L,Staroz F, Danhier S, Guillerm G, et al. Relapsingacute myeloid leukemia beginning with a penilelocalization. American Journal of Hematology. 2011;86(2): 193–194. https://doi.org/10.1002/ajh.21843.




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