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2026, Número 1

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Rev Fac Med UNAM 2026; 69 (1)


De la absorción a la acción: la fisiología de la vitamina B12

Esparza-Muñiz YA, Valdez-Martínez E

Idioma: Español
Referencias bibliográficas: 30
Paginas: 42-51
Archivo PDF: 485.65 Kb.


RESUMEN

En la formación de las y los estudiantes de medicina de pre y posgrado resulta fundamental fortalecer el conocimiento de la fisiología, por ser la base para comprender los mecanismos normales de funcionamiento del organismo e inferir los procesos de la pérdida de la salud. El desarrollo tecnológico en la medición de la concentración total sérica de la vitamina B12 , y de su fracción activa, tiene su sustento en el conocimiento fisiológico. Asimismo, dada la estrecha relación existente entre fisiología y fisiopatología, al analizar, por ejemplo, el funcionamiento de un organismo con niveles séricos anormalmente bajos o elevados de vitamina B12 , durante el curso de una enfermedad; el conocimiento de la fisiología de la vitamina B12 facilita imaginar los sucesos/procesos biológicos internos que pudieran explicar los hallazgos clínicos y de laboratorio. Este trabajo se enfoca en la fisiología de la vitamina B12 , presenta de manera fácil y lógica su estructura, su proceso de absorción, sus receptores celulares, sus proteínas transportadoras y de unión, y las rutas metabólicas clave en las que participa. Conocimiento que también puede ser usado como un ancla para futuros estudios de investigación científica.


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