Lugones LGY, Pérez CR, Morilla GA, Espinosa CI, Blanco HO

Idioma: Español
Referencias bibliográficas: 36
Paginas: 1-22
Archivo PDF: 315.79 Kb.

RESUMEN

Introducción: La eficacia de los antibióticos en enfermedades respiratorias es debatida, debido a que falla en alcanzar el área pulmonar infectada. El surfactante pulmonar es considerado un transportador de medicamentos debido a sus propiedades biofísicas.
Objetivo: Evaluar el efecto de Surfacen en la actividad de la cefotaxima y la amikacina frente a cepas asociadas a enfermedades respiratorias in vitro.
Métodos: La actividad antibacteriana de cefotaxima y amikacina solos o combinados con Surfacen®, se evaluó in vitro mediante la curva de letalidad en el tiempo de Staphylococcus aureus, Escherichia coli y Pseudomona aeruginosa, por el método de suspensión cuantitativa por dilución y conteo. Las definiciones estándar de sinergia, antagonismo o indiferencia se usaron para evaluar el efecto de Surfacen® en la actividad de los antibióticos.
Resultados: El Surfacen® no afecta la actividad antibacteriana de la cefotaxima o la aumenta al obtener un sinergismo a la concentración de 16 μg/mL para Staphylococcus aureus y a las concentraciones de 8 y 16 μg/mL para Pseudomona aeruginosa. En el caso de la amikacina si bien mostró indiferencia también se observó antagonismo, lo que es característico de los aminoglucósidos en presencia de surfactante pulmonar.
Conclusiones: El efecto de Surfacen en la actividad antibiótica fue investigado. Cuando se combina la cefotaxima con Surfacen no se afecta su actividad, sin embargo, la actividad de la amikacina se vio afectada, mostrando un comportamiento dual dependiente de la concentración. Este estudio contribuirá en el futuro al empleo de Surfacen como vehículo para el suministro de antibióticos al pulmón.

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