medigraphic.com
ISSN 2007-6509 (Impreso)
Órgano oficial de la Asociación Mexicana de Medicina Transfusional A.C.

2026, Número S1

<< Anterior Siguiente >>

Rev Mex Med Transfus 2026; 18 (S1)


Platelet transfusion refractoriness: diagnosis and management

Cohn CS

Idioma: Español
Referencias bibliográficas: 5
Paginas: 97-99
Archivo PDF: 126.95 Kb.


FRAGMENTO

Introduction Platelet transfusion refractoriness is a repeated suboptimal response to platelet transfusion, manifested by lower-than-expected posttransfusion platelet count increments. The first tasks are to confirm that the patient is truly refractory and to determine whether the cause is non-immune, immune, or a combination of both. Non-immune factors account for most cases, whereas immune-mediated refractoriness is less common but requires specialized testing and platelet selection.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Davis KB, Slichter SJ, Corash L. Corrected count increment andpercent platelet recovery as measures of posttransfusion plateletresponse: problems and a solution. Transfusion. 1999; 39 (6): 586-592. doi: 10.1046/j.1537-2995.1999.39060586.x.

  2. Stanworth SJ, Navarrete C, Estcourt L, Marsh J. Plateletrefractoriness—practical approaches and ongoing dilemmas inpatient management. Br J Haematol. 2015; 171 (3): 297-305. doi:10.1111/bjh.13597.

  3. Legler TJ, Fischer I, Dittmann J, Simson G, Lynen R, HumpeA et al. Frequency and causes of ref ractoriness in multiplytransfused patients. Ann Hematol. 1997;74(4):185-189. doi: 10.1007/s002770050280.

  4. Slichter SJ, Davis K, Enright H, Braine H, Gernsheimer T, KaoKJ et al. Factors affecting posttransfusion platelet increments,platelet refractoriness, and platelet transfusion intervals inthrombocytopenic patients. Blood. 2005; 105 (10): 4106-4114. doi:10.1182/blood-2003-08-2724.

  5. Kickler TS, Kennedy SD, Braine HG. Alloimmunization to plateletspecificantigens on glycoproteins IIb-IIIa and Ib/IX in multiplytransfused thrombocytopenic patients. Transfusion. 1990; 30 (7): 622-625. doi: 10.1046/j.1537-2995.1990.30790385520.x.




2020     |     www.medigraphic.com