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>Revistas >Salud Pública de México >Año 2006, No. 5

Hernández-Ruiz J, Becker I
Linfocitos T citotóxicos CD8+ en la leishmaniasis cutánea
salud publica mex 2006; 48 (5)

Idioma: Español
Referencias bibliográficas: 87
Paginas: 430-439
Archivo PDF: 180.60 Kb.

Texto completo


Objetivo. Examinar la bibliografía relacionada con la participación de los linfocitos T CD8+ en la reacción inmunitaria a especies de Leishmania causantes de leishmaniasis cutánea. En esta enfermedad se ha resaltado la intervención de macrófagos, células dendríticas, NK y células T CD4+; sin embargo, es poco lo que se conoce de las células T CD8+. Los trabajos en modelos murinos señalan que la participación de las células CD8+ sucede a través de la producción de IFN-gamma, aunque su capacidad citotóxica puede desempeñar una función importante, como lo demuestran los hallazgos en seres humanos. La forma como se activan las células citotóxicas CD8+ es un enigma. Es posible que las células dendríticas realicen esa labor a través de mecanismos que incluyen transpresentación de antígenos. Comprender la contribución de este subtipo celular en la respuesta inmunitaria a Leishmania aportará novedosos conocimientos sobre la fisiopatogenia de la leishmaniasis, lo cual hará posible desarrollar nuevos enfoques terapéuticos para esta parasitosis.

Palabras clave: leishmaniasis cutánea, linfocitos T CD8+, reacción inmunitaria, citotoxicidad, apoptosis.


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>Revistas >Salud Pública de México >Año2006, No. 5

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