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>Revistas >Gaceta Médica de México >Año 2006, No. 2


Quintero-Ramos A, Valdez-Velázquez LL, Hernández G, Baltazar LM, Padilla-Gutiérrez JR, Valle Y, Katya Rodarte, Ortiz R, Ortiz-Aranda M, Olivares N, Rivas F
Evaluación de cinco polimorfismos de genes trombofílicos en parejas con aborto habitual
Gac Med Mex 2006; 142 (2)

Idioma: Español
Referencias bibliográficas: 40
Paginas: 95-98
Archivo PDF: 432.49 Kb.


Texto completo




RESUMEN

Se han propuesto factores genéticos trombofílicos asociados con anormalidades obstétricas que implican la terminación temprana del embarazo. El propósito del estudio fue investigar la posible asociación de polimorfismos génicos trombofílicos con el aborto habitual (AH). Se analizaron muestras de dos grupos de personas que participaron voluntariamente en el estudio. El primero (n>100) consistió en mujeres atendidas en el Centro Médico de Occidente del Instituto Mexicano del Seguro Social y a sus parejas, por el antecedente reproductivo de por lo menos tres abortos idiopáticos (n>100). El grupo de referencia (n>200) lo formaron adultos sanos de ambos sexos residentes de Jalisco. El ADN se extrajo de una muestra de sangre periférica y se tipificaron, mediante PCR–RFLP o –SSP, los polimorfismos FII G20210A, FV G1691A, MTHFR C677T, ECA I/D y TNF G–308A. Las proporciones genotípicas en el grupo de referencia fueron similares a las predichas por la ley de Hardy–Weinberg y las comparaciones intergrupales alélicas, genotípicas y fenotípicas no mostraron diferencias significativas para ninguno de los polimorfismos estudiados. Estos resultados sugieren que los polimorfismos de los genes trombofílicos no representan un factor de riesgo para AH en nuestro medio.


Palabras clave: Aborto habitual, trombofilia, polimorfismos.


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