Godínez-Chaparro B, Guevara-López U, de la O-Arciniega M, Cortés-Arroyo AR, López-Muñoz FJ

Idioma: Español
Referencias bibliográficas: 41
Paginas: 371-376
Archivo PDF: 76.98 Kb.

RESUMEN

Los efectos antinociceptivos del metamizol y la morfina administrados individualmente o en combinación fueron determinados en Pain-induced functional impairment model in the rat (PIFIR). La nocicepción intensa (o dolor intenso) fue provocada por la inyección intraarticular de ácido úrico a 50% en la extremidad posterior derecha. Después los animales recibieron tratamiento farmacológico y fue evaluada la recuperación de la funcionalidad a través del tiempo, como una expresión de antinocicepción. El metamizol (177.8 mg/kg vía subcutánea) y la morfina (3.2 mg/kg vía subcutánea) por separado presentaron un efecto antinociceptivo bajo: 22.1 ± 5.4 y 31.8 ± 9.4 unidades de área, respectivamente. El efecto antinociceptivo con la combinación (293.7 ± 16.6 unidades de área) fue significativamente mayor que el esperado con la suma de los efectos individuales: el cambio fue de 444.9 %. Éste representa el primer estudio que demuestra que la combinación metamizol + morfina potencia los efectos antinociceptivos de los fármacos.

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