2007, Número 6
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Gac Med Mex 2007; 143 (6)
Estatinas, ¿alternativa terapéutica en sepsis?
Carrillo-Esper R, Rivera-Buendía S, Carrillo-Córdova JR, Carrillo-Córdova LD
Idioma: Español
Referencias bibliográficas: 35
Paginas: 499-503
Archivo PDF: 54.82 Kb.
RESUMEN
La sepsis es una causa importante de morbimortalidad. La evidencia derivada de estudios clínicos observacionales y de investigación en ciencias básicas, muestran que las estatinas pueden estar asociadas a reducción de la mortalidad en sepsis. Las estatinas tienen diversas propiedades inmunomoduladoras y antiinflamatorias independientemente de su efecto hipolipemiante. El efecto protector de las estatinas en sepsis persiste en grupos de alto riesgo incluyendo pacientes con diabetes mellitus, neoplasias malignas o que reciben esteroides. En este artículo se revisan y discuten las bases de estas observaciones y el papel de la terapia con estatinas en pacientes con sepsis. Este campo es de rápido crecimiento con base en la biología experimental. Los resultados de los diferentes estudios dictan la necesidad de investigar la farmacología de las estatinas en este nuevo escenario. Si los resultados del efecto benéfico de las estatinas en sepsis son confirmados con estudios prospectivos y controlados, las colocarían como una excelente alternativa terapéutica. Las estatinas son más económicas que otros tratamientos para el manejo de la sepsis, por lo que tendrían un gran impacto en el costo-beneficio del manejo de la sepsis.
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