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>Revistas >Medicina Interna de México >Año 2007, No. 4


Ruiz-Delgado GJ, Ruiz-Argüelles GJ, Ruiz-Reyes G
Dasatinib, una nueva molécula contra la leucemia
Med Int Mex 2007; 23 (4)

Idioma: Español
Referencias bibliográficas: 25
Paginas: 345-348
Archivo PDF: 130.76 Kb.


Texto completo




RESUMEN

El dasatinib (BMS-354825) es un inhibidor de la cinasa de tirosina BCR-ABL, cinasas SRC y otras cinasas oncogénicas. Es capaz de inhibir a 18 de 19 mutaciones BCR/ABL de las cinasas resistentes a su predecesor, el mesilato de imatinib. Impide la superproducción de las células cancerosas en la médula de los pacientes con leucemia granulocítica crónica o leucemia aguda linfoblástica con cromosoma Philadelphia+ que hayan mostrado resistencia o intolerancia a tratamientos anteriores con mesilato de imatinib (STI571) o nilotinib (AMN107).


Palabras clave: dasatinib, leucemia granulocítica crónica, leucemia aguda linfoblástica, cromosoma Philadelphia.


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>Revistas >Medicina Interna de México >Año2007, No. 4
 

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