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>Revistas >Gaceta Médica de México >Año 2008, No. 6


Almanza-Pérez JC, Blancas-Flores G, García-Macedo R, Alarcón-Aguilar FJ, Cruza M
Leptina y su relación con la obesidad y la diabetes mellitus tipo 2. J
Gac Med Mex 2008; 144 (6)

Idioma: Español
Referencias bibliográficas: 79
Paginas: 535-542
Archivo PDF: 118.92 Kb.


Texto completo




RESUMEN

En los últimos años, el número de pacientes con alteraciones metabólicas,tales como obesidad, diabetes mellitus tipo 2, hipertensión, etcétera, se ha incrementado. El aumento en el peso corporal, resultante de los factores genéticos, ambientales y nutricionales, tiene un papel muy importante en el desarrollo de diversas alteraciones metabólicas. En 1994 se describió al gen de la obesidad (ob) que codifica para la proteína leptina, molécula importante en la regulación del peso corporal. La ganancia en el peso normalmente correlaciona con un incremento de la proteína leptina, generándose a largo plazo un estado de resistencia a la misma. Además de esta relación con la obesidad, la leptina también se ha asociado con la diabetes mellitus tipo 2 y con la resistencia a la insulina, característica principal de esta patología. La leptina también se ha relacionado con otras enfermedades tales como cáncer, trastornos psicológicos y sexuales, entre otros. En este trabajo se analizan algunos aspectos bioquímicos y molecu lares relacionados con la fisiología de la leptina; se hace énfasis en las consecuencias patológicas que causan su desregulación en la obesidad y la diabetes mellitus tipo 2.


Palabras clave: Leptina, gen ob, adipocinas, tejido adiposo, obesidad, diabetes.


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