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>Revistas >Gaceta Médica de México >Año 2010, No. 2


González-Villalva AE, Falcón-Rodríguez CI, Fortoul-van der Goes TI
Vías de señalización implicadas en la megacariopoyesis
Gac Med Mex 2010; 146 (2)

Idioma: Español
Referencias bibliográficas: 68
Paginas: 136-143
Archivo PDF: 161.80 Kb.


Texto completo




RESUMEN

La hematotoxicología es un área poco estudiada en nuestro país y es limitado el conocimiento sobre el efecto que ciertos contaminantes atmosféricos inducen en la sangre y en la médula ósea. La contaminación por partículas suspendidas ha cobrado más interés, por los contaminantes que se adhieren a su superficie. Un ejemplo es el benceno, relacionado con aplasia medular y leucemia. Algunos metales que también están en las partículas inhaladas son hematotóxicos. Uno de ellos es el vanadio, que nuestro grupo ha identificado como un agente inductor de alteraciones en la megacariopoyesis, lo que motivó esta revisión. Las plaquetas desempeñan un papel muy importante en la hemostasia y derivan de la célula más grande de la médula ósea: el megacariocito. Hasta hace algunos años desconocíamos casi todo del megacariocito, pero con la clonación de la trombopoyetina, en 1994, la principal hormona reguladora de la producción plaquetaria, ha existido un desarrollo acelerado en el conocimiento de la megacariopoyesis. Este artículo hace una revisión de la megacariopoyesis y su regulación, con énfasis en las vías de señalización implicadas. Además, se mencionan algunas enfermedades relacionadas y se discuten las perspectivas de investigación de este proceso, con énfasis en la toxicología.


Palabras clave: Megacariopoyesis, plaquetas, trombopoyetina, señalización.


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>Revistas >Gaceta Médica de México >Año2010, No. 2
 

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