medigraphic.com
Coordinación General de Investigación de la Facultad de Salud Pública y Nutrición y la Dirección General de Sistemas e Informática de la Universidad Autónoma de Nuevo León

2010, Número 1

<< Anterior Siguiente >>

Rev Salud Publica Nutr 2010; 11 (1)


Alimentación: Su impacto sobre el sistema inmune y cáncer

Miranda-Hernández DF, Franco-Molina MA, Rivera-Morales LG, Rodríguez-Padilla C

Idioma: Español
Referencias bibliográficas: 31
Paginas:
Archivo PDF: 139.61 Kb.


RESUMEN

Un sistema de medicina integral es necesario para el tratamiento del cáncer debido a que las actuales medidas aplicadas a pacientes con esta enfermedad están enfocadas principalmente en la administración de quimioterapia, radioterapia y anticuerpos monoclonales en diversos tipos de cáncer sin tomar en cuenta la participación del sistema psiconeuroinmunológico y nutrimental siendo estos los encargados del control de la homeostasis celular. En esta revisión estudiaremos los mecanismos que relacionan la alimentación con el sistema inmune y el desarrollo del cáncer, así como los mecanismos implicados en la generación de un tipo de células inmunosupresoras llamadas células T reguladoras que están relacionadas con el desarrollo y progresión tumoral.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Burnet FM. 1957. Cancer a biological approach. Br Med J 1:841–7.

  2. Thomas L. 1959. Cellular and humoral aspects of the hypersensitive states. New York: Hoeber-Harper;.

  3. Schreiber TH and ER Podack 2009. A critical analysis of the tumour immunosurveillance controversy for 3-MCAinduced sarcomas. Br J Cancer.; 3:381-6.

  4. Aguirre JA. 2007.Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer;7:834–46.

  5. Udagawa Taturo 2008. Tumor dormancy of primary and secondary cancers. APMIS; 116: 615-628.

  6. Dunn GP, AT Bruce , H Ikeda , LJ Old and RD Schreiber 2002. Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol.; 11:991-8.

  7. Alan B. and M Ngozi 2006. Effector-phase tolerance: another mechanism of how cancer escapes antitumor immune response. J. Leukoc. Biol; 79: 652-662.

  8. Markus F, A Jonathan, M Diane, B Christophe 2009. Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nature Immunology; 10:689-695.

  9. Bubenik J. 2006. Depletion of Treg Cells Augments the Therapeutic Effect of Cancer Vaccines. Folia Biologica (Praha);.52: 202-204.

  10. Yasmine B. and O Guillaume 2008. Tuning microenviroments: induction of regulatory T cells by dendritic cells. Immunity; 29: 362-371.

  11. Paul A. and P Nicholas 2005. CD4+CD25+ T Regulatory Cells, Immunotherapy of Cancer, and Interleukin-2. J Immunother; 28: 120–128.

  12. Idem.

  13. Idem.

  14. . Sheng X, J Hulin, K Thomas, M Sue, O Mohamed, L Bing and K Vijay 2008. Retinoic Acid Increases Foxp3+ Regulatory T Cells and Inhibits Development of Th17 Cells by Enhancing TGF-β-Driven Smad3 Signaling and Inhibiting IL-6 and IL-23 Receptor Expression. The Journal of Immunology; 181:2277 -2284

  15. Schmidt S. et al. 2004. Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NFkB activation. Proc. Natl. Acad. Sci. USA; 101: 4566-4571.

  16. Idem.

  17. Bharat B and S Shishir 2004. Suppression of Nuclear Factor-kappa B Activation Pathway by Spice-Derived Phytochemicals: Reasoning for seasoning. Ann N Y Acad Sci. Dec;1030:434-41.

  18. Paolo L, M Giusy, B Fernando, F Luca, V Luigi, R Franco, M Luisa, M Mauro., et al 2008. Modulation of the anticancer immunity by natural agents: inhibition of T regulatory lymphocytegeneration by arabinoxylan in patients with locally limited or metastatic solid tumors. Cancer Therapy; 6:1011-1016.

  19. Singh S, K Natarajan, B Aggarwal 1996. Capsaicin (8-methyl-N-vanillyl-6- nonenamide) is a potent inhibitor of nuclear transcription factor-kappa B activation by diverse agents. J Immunol; 157: 4412-20.

  20. Singh, S. and B. B. Aggarwal 1995. Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane). J Biol Chem; 270: 24995-5000.

  21. Shishodia, S., et al. 2003. Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1. Cancer Res.; 63: 4375-83.

  22. Geng, Z., Y. Rong and B. H. Lau 1997. S-allyl cysteine inhibits activation of nuclear factor kappa B in human T cells. Free Radic Biol Med; 23: 345-50.

  23. Salminena A, M Lehtonenc, T Suuronena, K Kaarnirantad and J Huuskonen 2008. Terpenoids: natural inhibitors of NF-κB signaling with anti-inflammatory and anticancer potential. Cell. Mol. Life Sci.; 65: 2979 – 2999.

  24. Idem.

  25. Ide, N. and B. H. Lau 2001. Garlic compounds minimize intracellular oxidative stress and inhibit nuclear factorkappa b activation. J Nutr; 131: 1020S-6S.

  26. Idem.

  27. 27.. Kunnumakkara AB, S Guha, S Krishnan, et al 2007. Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. Cancer Res.; 67:3853-61.

  28. Seung G, W Chuanwu, M Satoshi and H Chang 2009. High and low vitamin A therapies induce distinct FoxP3+ T cell subsets and effectively control intestinal inflammation. J.Gastro.. Article in Press.

  29. Abadias M, J Usall , M Anguera , C Solsona and I Viñas 2008. Microbiological quality of fresh, minimallyprocessed fruit and vegetables, and sprouts from retail establishments. Int J Food Microbiol.; 123:121-9.

  30. Toshio W, N Hikaru, T Tetsuya, Y Hirokazu, O Hirotoshi, W Kenji, T Kazunari., et al 2009. Probiotic Lactobacillus casei strain Shirota prevents indomethacin-induced small intestinal injury-Involvement of lactic acid. Am J Physiol Gastrointest Liver Physiol. Sep;297(3):G506-13.

  31. Idem.




2020     |     www.medigraphic.com