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2010, Número S1

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Rev Mex Anest 2010; 33 (S1)


Estatinas en el período perioperatorio

Carrillo-Esper R, Sosa-García JO

Idioma: Español
Referencias bibliográficas: 22
Paginas: 172-174
Archivo PDF: 96.81 Kb.


FRAGMENTO

Introducción

Endo, en 1976 aisló las estatinas a partir del moho Penicillium citrinium. La primera estatina estudiada en seres humanos fue la mevastatina. Albert, creó la primera estatina (Lovastatina), aislada de Aspergillus terreus y aprobada para uso en seres humanos.
Las estatinas son altamente efectivas reduciendo los niveles plasmáticos de colesterol al inhibir de manera competitiva la 3-hidroxi-3-metil-glutaril coenzima A reductasa (HMG-CoA reductasa), disminuyendo los niveles plasmáticos de colesterol total (60-65%), lipoproteínas de baja densidad (LDL) del 25-40%, triglicéridos e incrementando las lipoproteínas de alta densidad (HDL) en un 5-20%.


REFERENCIAS (EN ESTE ARTÍCULO)

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  2. Alberts AW, Chen J, Kuron G, Hunt V, Huff J, et al. Mevinolin: A highly potent competitive inhibitor of hydroxymethylglutaryl- coenzyme A reductase and a cholesterol-lowering agent. Proc Nat Acad Sci 1980;77:3957-3961.

  3. Ray KK, Cannon CP. The potential relevance of the multiple lipid-independent (pleiotropic) effects of statins in the management of acute coronary syndromes. J Am Coll Cardiol 2005;46:1425-1433.

  4. Yannick LM, Coriat P, Collard CD, Riedel B. Statin therapy within the perioperative period. Anesthesiology 2008;108:1141-1146.

  5. Chan YC, Cheng SW, Irwin MG. Perioperative use of statins in noncardiac surgery. Vascular Health and Risk Management 2008;4:75-81.

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  14. O’Neil-Callahan K, Katsimaglis G, Tepper MR, Ryan J, Mosby C, et al. Statins decrease perioperative cardiac complications in patients undergoing noncardiac vascular surgery: the Statins for Risk Reduction in Surgery (StaRRS) study. J Am Coll Cardiol 2005;45:336-42.

  15. Durazzo AE, Machado FS, Ikeoka DT, De Bernoche C, Monachini MC, et al. Reduction in cardiovascular events after vascular surgery with atorvastatin: A randomized trial. J Vasc Surg 2004;39:967-76.

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