medigraphic.com
Órgano Oficial del Instituto de Ciencias de la Salud, Hospital Escuela y Facultad de Medicina-Xalapa

2008, Número S1

<< Anterior Siguiente >>

Rev Med UV 2008; 8 (S1)


Regulación genética de matrix metaloproteasas y sus inhibidores

Sampieri RCL

Idioma: Español
Referencias bibliográficas: 21
Paginas: 14-17
Archivo PDF: 105.95 Kb.


FRAGMENTO

Las matrix metaloproteinasas (MMPs) humanas se agrupan en una familia de 24 endopeptidasas que degradan virtualmente todos los componentes de la matrix extracelular. Las MMPs participan en varios procesos fisiológicos, tales como ovulación, migración celular, angiogénesis, implantación y desarrollo embrional.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Chang, C.; Werb, Z. (2001). The many faces of metalloproteases: cell growth, invasíon, angiogenesis and metastasís. Trends in Cell Biology. 11, S37-S43

  2. Egeblad, M.; Werb, Z. (2002). New functions for the matrix metalloproteinases in cancer progression. Nature Rev. Cancer. 2, 161-174

  3. López-Otín, C.; Overall, C.M. (2002). Protease degradomics: a new challenge for proteomics. Nature Rev. Mol. Cell Biol. 3, 509-519

  4. Puente, X.S.; Sánchez, L.M.; Overall, C.M.; López-Otín, C. (2003). Human and mouse proteases: a comparative genomic approach. Nature Rev. Genet. 4, 544-558

  5. Overall, C.M., López-Otín, C. (2002). Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nature Rev. Cancer. 2, 657-672

  6. Edwards, D.R., Murphy, G., Reynolds, J.J., Whitman, S.E., Docherty, A.J P., Angel, P., Heath, J.K. (1987). Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J. 6, 1899- 1904

  7. Edwards, D.R., Rocheleau, H., Sharma, R.R., Wills, A.J., Cowie, A., Hassell, J.A., Heath, J.K. (1992). Involvement of AP1 and PEA3 binding sites in the regulation of murine tissue inhibitor of metalloproteinases-1 (TIMP-1) transcription. Biochim. Biophys. Acta. 1171, 41-55

  8. Baker, A.H.; Edwards, D.R.; Murphy, G. (2002). Metalloproteinase inhibitors: biological actions and therapeutic opportunities. J. Cell Sci. 115, 3719-3727

  9. Yan, C., Boyd, D.D. 2007. Regulation of matrix metalloproteinase gene expression. J. Cell Physiol. 211, 19-26

  10. Borden, P., Heller, R.A. 1997. Transcriptional control of matrix metalloproteinases and the tissue inhibitors of matrix metalloproteinases. Crit. Rev. Eukaryot. Gene Expr. 7, 159-178

  11. Westermarck, J., Li, S.P., Kallunki, T., Han, J., Kähäri, V.M. 2001. p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression. Mol. Cell. Biol. 21, 2373-2383

  12. Vincenti, M.P., Brinckerhoff, C.E. 2002. Transcriptional regulation of collagenase (MMP- 1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors. Arthritis Res. 4, 157-164

  13. Reunanen, N., Li, S. P., Ahonen, M., Foschi, M., Han, J., Kähäri, V. M. 2002. Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization. J. Biol. Chem. 277, 32360-32368

  14. Hall, M.C., Young, D.A., Waters, J.G., Rowan, A.D., Chantry, A., Edwards, D.R., Clark, I.M. 2003. The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1. J. Biol. Chem. 278, 10304-10313

  15. Cano, E., Mahadevan, L.C. 1995. Parallel signal processing among mammalian MAPKs. Trends Biochem. Sci. 20, 117-122

  16. Pearson, G., Robinson, F., Gibson, T.B., Xu, B.E., Karandikar, M., Berman, K., Cobb M.H.2001. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr. Rev. 22, 153-183

  17. Hazzalin, C.A., Mahadevan, L.C. 2002. MAPKregulated transcription: a continuously variable gene switch? Nature Rev. Mol. Cell Biol. 3, 30-40

  18. Yang, S.H., Sharrocks A.D., Whitmarsh, A.J. 2003. Transcriptional regulation by the MAP kinase signaling cascades. Gene. 320, 3-21

  19. Auble, D.T., Brinckerhoff, C.E. 1991. The AP-1 sequence is necessary but not sufficient for phorbol induction of collagenase in fibroblasts. Biochemistry. 30, 4629-4635

  20. McDonnell, S.E., Kerr, L.D., Matrisian, L.M. 1990. Epidermal growth factor stimulation of stromelysin mRNA in rat fibroblasts requires induction of proto-oncogenes c-fos and c-jun and activation of protein kinase C. Mol. Cell. Biol. 10, 4284-4293

  21. Hu, E., Mueller, E., Oliviero, S., Papaioannou, V.E., Johnson, R., Spiegelman, B.M. 1994. Targeted disruption of the c-fos gene demonstrates c-fos-dependent and -independent pathways for gene expression stimulated by growth factors or oncogenes. EMBO J. 13, 3094-3103




2020     |     www.medigraphic.com