Gómez VF

Idioma: Español
Referencias bibliográficas: 20
Paginas: 107-114
Archivo PDF: 521.35 Kb.

RESUMEN

El Sildenafil es un medicamento que ha demostrado ser eficaz para el tratamiento de la disfunción eréctil. Desde su aparición se han reportado casos anecdóticos que sugerían la asociación entreel medicamento y efectos coronarios adversos. Múltiples ensayos clínicos han estudiado los efectos del fármaco en el sistema cardiovascular. Ninguno ha reportado un incremento de eventos cardiacos adversos al utilizar el medicamento. El consenso de Princeton de Disfunción Eréctil y Enfermedad cardiovascular establece las guías clínicas según la evidencia existente, e insiste en la adecuada estratificación del paciente antes de iniciar/continuar la actividad sexual.

REFERENCIAS (EN ESTE ARTÍCULO)

1. Arruda-Olson AM, Mahoney DW, Nehra A, Leckel M, Pellikka PA. Cardiovascular effects of sildenafil during exercise in men with known or probable coronary artery disease: a randomised crossover trial. JAMA 2002;287:719-25.

2. Canales JM, Bustamante F-Uso de sildenafil en hombres con cardiopatía coronaria: Consideraciones clínicas y epidemiológicas Revista Mexicana de Cardiología Abril-Junio 1999 Vol 10, Número 2 pp 85-89.

3. Carson C. Cardiac Safety in Clinical Trials of Phosphodiesterase 5 Inhibitors. Am J Cardiol 2005; 96[suppl]:37M–41M)

4. Cheitlin M, Cochair A, Hutter A, Brindis R, Ganz P, Kaul S, Russell R, Zusman R. ACC/AHA Expert Consensus Document. Use of sildenafil (Viagra) in patients with cardiovascular disease. J Am Coll Cardiol 1999; 33: 273-82.

5. Cheitlin M, Hutter AM, Brindis RG, Ganz P, Kaul S, Russel RO et al. Use of sildenafil in patients with cardiovascular disease: AHA/ACC Expert Consensus Document. J Am Coll Card 1999; 33: 273-82.

6. Conti C, Pepine C, Sweeney M Efficacy and safety of sildenafil citrate in the treatment of erectile dysfunction in patients with ischemic heart disease. American Journal of Cardiology, 1999, 83,Sup 1 29-34

7. DeBusk R, Pepine C, Glasser D, Shpilsky A, DeRiesthal H, Sweeney M. Efficacy and Safety of Sildenafil Citratein Men With Erectile Dysfunction and Stable Coronary Artery Disease. Am J Cardiol 2004;93:147–153

8. Drogo K. Montague, Jonathan P. Jarow, Gregory A. Broderick, Roger R. Dmochowski, Jeremy P.W. Heaton, Tom F. Lue, Aaron J. Milbank, Ajay Nehra, Ira D. Sharlip. American Urological Association. Management of Erectile Dysfunction. Chapter 1 with Appendix: Diagnosis and Treatment Guideline. 2005. Disponible en: http://www.auanet.org/content/guidelines-and-quality-care/clinical-guidelines/main-reports/edmgmt/chapter1.pdf año 2006

9. Drory Y, Fisman EZ, Shapira Y, Puines A. Ventricular arrhythmia during sexual activity in patients with coronary artery disease. Chest 1996; 109: 992-4.

10. Fink H, Mac Donald M, Rutks I,Nelson D,Wilt T. Sildenafil for Male Erectile Dysfunction A Systematic Review and Meta-analysis Arch Intern Med 2002, 162; 1349

11. Fox K, Thadani U, Ma P, Nash, Keating Z, Czorniak M, Gillies H, Keltai Mon Sildenafil citrate does not reduce exercise tolerance in men with erectile dysfunction and chronic stable angina European Heart Journal (2003) 24, 2206–2212

12. Guimarães A, Bolívar M, Rizzi O, Zilli E, Luna R. Use of Sildenafil in Patients with Cardiovascular Disease Arq Bras Cardiol 1999; 73: 38-42

13. Halcox J, Nour K, Zalos G, Mincemoyer R, Waclawiw M. Rivera C et al. The Effect of Sildenafil on Human Vascular Function, Platelet Activation, and Myocardial Ischemia J Am Coll Cardiol, 2002; 40:1232-1240

14. Herrmann H.C, Chang G, Klugherz B. D., Hemodinamic Effects of Sildenafil in Men with Severe Coronary Artery Disease. NEJM 2000, 342:1622-1626.

15. Kloner Robert A.. Sex and the Patient with Cardiovascular Risk Factors: Focus on Sildenafil Am J Med. 2000;109(9A):13S–21S

16. Kostis J, Jackson G, Rosen R, Barrett-Connor E, Billups K, Burnett A, Carson C, Cheitlin M et al. Sexual Dysfunction and Cardiac Risk (the Second Princeton Consensus Conference. Am J Cardiol 2005;96:313–321

17. Mittleman MA, Glasser DB, Orazem J. Clinical trials of sildenafil citrate (Viagra) demonstrate no increase in risk of myocardial infarction and cardiovascular death compared with placebo. Int J Clin Pract 2003;57:597–600.

18. Mittleman M, Maclure M, Glasser D. Evaluation of Acute Risk for Myocardial Infarction in Men Treated With Sildenafil Citrate Am J Cardiol 2005; 96: 443-446

19. Olsson A. Sildenafil appears safe for men with cardiovascular disease but further study is recommended. Geriatrics; 2000;55: 69-70.

20. Patrizi R, Leonardo F, Pelliccia F, Chierchia SL, Galetta P, Cerquetani E, et al. Effect of sildenafil citrate upon myocardial ischemia in patients with chronic stable angina in therapy with beta-blockers. Ital Heart J 2001; 2 (11): 841-844)