2011, Número 25
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Hipoc Rev Med 2011; 6 (25)
Beta-bloqueadores en Insuficiencia Cardiaca Sistólica
Esparragoza-Fox C, Padilla-Ibarra J, Esparragoza-Romano JE
Idioma: Español
Referencias bibliográficas: 35
Paginas: 6-13
Archivo PDF: 122.52 Kb.
RESUMEN
El conocimiento del mecanismo de acción de los beta-bloqueadores en el sistema simpático, nos ha llevado al controvertido uso de estos en la insuficiencia cardiaca. A pesar de sus efectos antagonistas en las funciones cronotrópicas e inotrópicas del corazón, actualmente forman parte del tratamiento avalado por la FDA para insuficiencia cardiaca. Con el uso de beta-bloqueadores se ha observado la disminución de agentes pro-inflamatorios así como vasoconstrictores, inhibiendo la activación del sistema neuro-hormonal del sistema simpático en respuesta al bajo gasto; factores que si no se controlan, perpetuarían el daño de la insuficiencia cardiaca.
Durante los últimos años, múltiples estudios clínicos se han realizado principalmente con el uso de metoprolol, carvedilol y bisoprolol, dando resultados muy favorables, aumentando la sobrevida y disminuyendo los síntomas, numero de hospitalizaciones así como la mortalidad en pacientes con insuficiencia cardiaca. Como objetivo analizaremos los diferentes estudios realizados con el uso de beta-bloqueadores en la insuficiencia cardiaca, además de sus resultados.
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