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>Revistas >MediSan >Año 2012, No. 01

Clapé LO, Alfonso CA
Avances en la caracterización farmacotoxicológica de la planta medicinal Curcuma longa Linn
MediSan 2012; 16 (01)

Idioma: Español
Referencias bibliográficas: 54
Paginas: 97-114
Archivo PDF: 380.80 Kb.

[Texto completo - PDF]


Las plantas medicinales, por sus innumerables propiedades terapéuticas (antioxidante, antiinflamatoria, anticancerígeno y antiinfecciosa, entre otras) han mostrado ser sumamente eficaces en todas las civilizaciones. Con el desarrollo de las investigaciones actuales en esta materia, existen en Cuba grandes posibilidades de obtener nuevos fitofármacos con bajo potencial de reacciones adversas. A tales efectos se realizó una revisión bibliográfica con vistas a exponer los avances en la caracterización farmacotoxicológica de la planta Curcuma longa Linn para completar así la información disponible en las bases de datos nacionales al respecto.

Palabras clave: Curcuma longa Linn, farmacotoxicología, fitofármaco, planta medicinal, reacción adversa medicamentosa.


  1. Sánchez LA, Fonseca LG, Capiro TC, Fernández FD. Propuesta de una ruta crítica para la evaluación genotóxica de plantas medicinales en Cuba. Rev Cubana Farm 2000; 34(1):34-43.

  2. Raigorodsky CG, Torres EM. Documentos soporte para la gestión de la actividad de investigación- desarrollo en plantas medicinales. Rev Cubana Plant Med 2004; 9(2). [consulta: 22 julio 2011].

  3. González RM, Ramírez D, Jacobo OL. Antecedentes y situación reguladora de la medicina herbaria en Cuba. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas (BLACPMA) 2007; 6(4):118–24.

  4. Ortega T, Carretero MT, Pascual E, Villar AM. Antiinflamatory activity of ethanolic extracts of plants used in traditional medicine in Ecuador. Phytoter Res 1996; 10: 121-2.

  5. Cuba. Ministerio de Salud Pública. Yuquilla. FITOMED II: plantas medicinales. La Habana: MINSAP, 1993:116-17.

  6. Goldberg A. Monograph of Curcuma longa. Therapeutic guide to herbal medicines. Boston: American Botanical Council, 1998.

  7. Singh G, Kapoor IP, Singh P, de Heluani CS, de Lampasona MP, Catalan CA. Comparative study of chemical composition and antioxidant activity of fresh and dry rhizomes of turmeric (Curcuma longa Linn). Food Chem Toxicol 2010; 48(4):1026-31.

  8. Nagarathnam R, Rengasamy A, Balasubramanian R. Purification and properties of cysteine protease from rhizomes of Curcuma longa Linn. J Sci Food Agric 2010; 90(1):97-105.

  9. Gota VS, Maru GB, Soni TG, Gandhi TR, Kochar N, Agarwal MG. Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. J Agric Food Chem 2010; 58(4):2095-9.

  10. Hassaninasab A, Hashimoto Y, Tomita-Yokotani K, Kobayashi M. Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. Proc Natl Acad Sci USA 2011; 108(16):6615-20.

  11. Arteche GA, Vanalocha VB, Güenechea SJ. Monografía de Curcuma longa. Vademecum de prescripción de plantas medicinales [monografía en CD-ROM]. Barcelona: Masson, 1999.

  12. Kuttan AS, Kuttan G. Immunomodulatory activity of curcumin. Immunol Invest 1999; 23(5-6):291–303.

  13. Tilak JC, Banerjee M, Mohan H. Antioxidant availability of turmeric in relation to its medicinal and culinary uses. Phytother Res 2004; 18(10):798-804.

  14. Ramsewak RS, Dewitt DL, Nair MG. Cytoxicity, antioxidant and antiinflamatory activities of curcumins I–III from Curcuma longa. Phytomedicine 2000; 7(4): 303-8.

  15. Mukherjee S, Roy M, Dey S, Bhattacharya RK. A mechanistic approach for modulation of arsenic toxicity in human lymphocytes by Curcumin an active constituent of medicinal herb Curcuma longa Linn. J Clin Biochem Nutr 2007; 41(1):32–42.

  16. Karim MR, Haque A, Islam K, Ali N, Salam KA, Saud ZA, et al. Protective effects of the dietary supplementation of turmeric (Curcuma longa L.) on sodium arseniteinduced biochemical perturbation in mice. Bangladesh Med Res Counc Bull 2010; 36(3):82-8.

  17. Farombi EO, Abarikwu SO, Adedara IA, Oyeyemi MO. Curcumin and kolaviron ameliorate di-n-butylphthalate-induced testicular damage in rats. Basic Clin Pharmacol Toxicol 2007; 100(1):43-8.

  18. Cao J, Liu Y, Jia L, Jiang LP, Geng CY, Yao XF, et al. Curcumin attenuates acrylamide-induced cytotoxicity and genotoxicity in HepG2 cells by ROS scavenging. J Agric Food Chem 2008; 56(24):12059-63.

  19. Kheradpezhouh E, Panjehshahin MR, Miri R, Javidnia K, Noorafshan A, Monabati A, et al. Curcumin protects rats against acetaminophen-induced hepatorenal damages and shows synergistic activity with N-acetyl cysteine. Eur J Pharmacol 2010; 628(1-3):274-81.

  20. Lee HS, Li L, Kim HK, Bilehal D, Li W, Lee DS, et al. The protective effects of Curcuma longa Linn. Extract on carbon tetrachloride-induced hepatotoxicity in rats via upregulation of Nrf2. J Microbiol Biotechnol 2010; 20(9):1331-8.

  21. Bao W, Li K, Rong S, Yao P, Hao L, Ying C, et al. Curcumin alleviates ethanolinduced hepatocytes oxidative damage involving heme oxygenase-1 induction. J Ethnopharmacol 2010; 128(2):549-53.

  22. Lima CF, Pereira-Wilson C, Rattan SI. Curcumin induces heme oxygenase-1 in normal human skin fibroblasts through redox signaling: relevance for anti-aging intervention. Mol Nutr Food Res 2011; 55(3):430-42.

  23. Jaisin Y, Thampithak A, Meesarapee B, Ratanachamnong P, Suksamrarn A, Phivthong-Ngam L, et al. Curcumin I protects the dopaminergic cell line SH-SY5Y from 6-hydroxydopamine-induced neurotoxicity through attenuation of p53- mediated apoptosis. Neurosci Lett 2011; 489(3):192-6.

  24. Deodhar SD, Sethi R, Srimal RC. Preliminary study on antirheumatic activity of curcumin (diferuloyl methane). Indian J Med Res 1980; 71:632-4.

  25. Kulkarni RR, Patki PS, Jog VP, et al. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol 1991; 33(1-2):91-5.

  26. Nonn L, Duong D, Peehl DM. Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells. Carcinogenesis 2007; 28(6):1188-96.

  27. Mito S, Watanabe K, Harima M, Thandavarayan RA, Veeraveedu PT, Sukumaran V, et al. Curcumin ameliorates cardiac inflammation in rats with autoimmune myocarditis. Biol Pharm Bull 2011; 34(7):974-9.

  28. Yue GG, Chan BC, Hon PM, Kennelly EJ, Yeung SK, Cassileth BR, et al. Immunostimulatory activities of polysaccharide extract isolated from Curcuma longa. Int J Biol Macromol 2010; 47(3):342-7.

  29. Curcumin possible help for skin cancer [consulta: 22 julio 2011].

  30. Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res 2003; 23(1A):363-98.

  31. Chakraborty S, Ghosh U, Bhattacharyya NP, Bhattacharya RK, Roy M. Inhibition of telomerase activity and induction of apoptosis by curcumin in K-562 cells. Mutat Res 2006; 596(1-2):81-90.

  32. Dikmen M, Canturk Z, Ozturk Y, Tunali Y. Investigation of the apoptotic effect of curcumin in human leukemia HL-60 cells by using flow cytometry. Cancer Biother Radiopharm 2010; 25(6):749-55.

  33. Yallapu MM, Jaggi M, Chauhan SC. Beta-cyclodextrin-curcumin self-assembly enhances curcumin delivery in prostate cancer cells. Colloids Surf B Biointerfaces 2010; 79(1):113-25.

  34. Chiu TL, Su CC. Curcumin inhibits proliferation and migration by increasing the bax to Bcl-2 ratio and decreasing NF-kappaB p65 expression in breast cancer MDA-MB-231 cells. Int J Mol Med 2009; 23(4):469-75.

  35. Chen L, Tian G, Shao C, Cobos E, Gao W. Curcumin modulates eukaryotic initiation factors in human lung adenocarcinoma epithelial cells. Mol Biol Rep 2010; 37(7):3105-10.

  36. Saha A, Kuzuhara T, Echigo N, Fujii A, Suganuma M, Fujiki H. Apoptosis of human lung cancer cells by curcumin mediated through up-regulation of "growth arrest and DNA damage inducible genes 45 and 153". Biol Pharm Bull. 2010; 33(8): 1291-9.

  37. ----. New role of (-)-epicatechin in enhancing the induction of growth inhibition and apoptosis in human lung cancer cells by curcumin. Cancer Prev Res (Phila) 2010; 3(8):953-62.

  38. Tharakan ST, Inamoto T, Sung B, Aggarwal BB, Kamat AM. Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers. Biochem Pharmacol 2010; 79(2):218-28.

  39. Lu JJ, Cai YJ, Ding J. Curcumin induces DNA damage and caffeine-insensitive cell cycle arrest in colorectal carcinoma HCT116 cells. Mol Cell Biochem 2011; 354(1- 2):247-52.

  40. Van Dau N, Ngoc Ham N, Huy Khac D. The effects of a traditional drug, turmeric (Curcuma longa), and placebo on the healing of duodenal ulcer. Phytomed 1998; 5(1):29-34.

  41. Kositchaiwat C, Kositchaiwat S, Havanondha J. Curcuma longa Linn in the treatment of gastric ulcer comparison to liquid antacid: a controlled clinical trial. J Med Assoc Thai 1993; 76(11):601-5.

  42. Kim J, Ha HL, Moon HB, Lee YW, Cho CK, Yoo HS, et al. Chemopreventive effect of Curcuma longa Linn on liver pathology in HBx transgenic mice. Integr Cancer Ther 2011; 10(2):168-77.

  43. Lin YL, Lin CY, Chi CW, Huang YT. Study on antifibrotic effects of curcumin in rat hepatic stellate cells. Phytother Res 2009; 23(7):927-32.

  44. Kang C, Kim E. Synergistic effect of curcumin and insulin on muscle cell glucose metabolism. Food Chem Toxicol 2010; 48(8-9):2366-73.

  45. El-Moselhy MA, Taye A, Sharkawi SS, El-Sisi SF, Ahmed AF. The antihyperglycemic effect of curcumin in high fat diet fed rats. Role of TNF-α and free fatty acids. Food Chem Toxicol 2011; 49(5):1129-40.

  46. Adaramoye OA, Medeiros IA. Involvement of Na (+)-Ca (2+) exchanger in the endothelium-independent vasorelaxation induced by Curcuma longa L in isolated rat superior mesenteric arteries. J Smooth Muscle Res 2008; 44(5):151-8.

  47. Prakash P, Misra A, Surin WR, Jain M, Bhatta RS, Pal R, et al. Anti-platelet effects of Curcuma oil in experimental models of myocardial ischemia-reperfusion and thrombosis. Thromb Res 2011; 127(2):111-8.

  48. Priyanka R, Preeti D, Saurabh V, Aparajita R, Uma Sh, Jaganathanan NR, et al. Curcuma oil: reduces early accumulation of oxidative product and is antiapoptogenic in transient focal ischemia in rat brain. Neurochemical Research 2008; 33(9):1672-82.

  49. Ahmed T, Gilani AH. Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease. Pharmacol Biochem Behav 2009; 91(4): 554-9.

  50. Taher MM, Lammering G, Hershey Ch, Valerie K. Curcumin inhibits ultraviolet light induced human immunodeficiency virus gene expression. Mol Cell Biochem 2003; 254(1-2):289-97.

  51. Nagarathnam R, Rengasamy A, Balasubramanian R. Purification and properties of cysteine protease from rhizomes of Curcuma longa Linn. J Sci Food Agric 2010; 90(1):97-105.

  52. Nayak S, Sashidhar RB. Metabolic intervention of aflatoxin B1 toxicity by curcumin. J Ethnopharmacol 2010; 127(3):641-4.

  53. Vistel M. Expediente de registro de un comprimido de Curcuma longa L. Santiago de Cuba: Laboratorio Farmacéutico Oriente, 2002.

  54. Nishiyama T, Mae T, Kishida H, Tsukagawa M, Mimaki Y, Kuroda M, et al. Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice. J Agric Food Chem 2005; 53 (4):959-63.

>Revistas >MediSan >Año2012, No. 01

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