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>Revistas >Revista de Hematología >Año 2011, No. 1


Cáceres-Cortés JR
Factor Steel: lecciones de supervivencia celular
Rev Hematol Mex 2011; 12 (1)

Idioma: Español
Referencias bibliográficas: 48
Paginas: 32-38
Archivo PDF: 106.90 Kb.


Texto completo


RESUMEN

Los ratones portadores de mutaciones en cualquiera de los loci dominant white spotting (W) y Steel (Sl), tienen defectos serios en el desarrollo de tres diferentes linajes celulares con actividad migratoria: melanocitos, gametos y células hematopoyéticas. El análisis genético ha revelado que el locus Sl codifica para el factor Steel, que es el ligando del receptor de tipo tirosina cinasa c-Kit que es producto del locus W. El factor Steel juega un papel decisivo en la formación de células hematopoyéticas. Recientemente se pudo establecer que regula el autorrenuevo, la diferenciación y muerte celular durante la generación de células hematopoyéticas, actúa como un factor de supervivencia. Entender cómo las células primitivas hematopoyéticas sufren una restricción progresiva en su potencial de diferenciación y adquieren características de células maduras bajo el efecto del factor Steel, representa un reto importante en biología celular. El patrón en la expresión genética en una célula está establecido por factores de transcripción que regulan procesos antagónicos como la supervivencia y la muerte celular. Aquí se explica que el efecto de supervivencia del factor Steel está modulado por el factor de transcripción de tipo básico hélice-asa-hélice SCL. Las propiedades mostradas por el factor Steel indican que juega un papel decisivo en la potenciación de la proliferación y supervivencia celular durante el desarrollo de los progenitores hematopoyéticos y no hematopoyéticos.


Palabras clave: factor Steel, SCL, factores de transcripción.


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