Díaz-Hung ML, González ME, Fernández I, Horruitiner I, Piedra S

Idioma: Ingles.
Referencias bibliográficas: 38
Paginas: 250-254
Archivo PDF: 266.32 Kb.

RESUMEN

El glutatión es un importante antioxidante celular, cuya disminución promueve el daño oxidativo y altera las interacciones sinápticas, a corto y a largo plazo. Su función en el aprendizaje y la memoria ha sido poco estudiada. Se decidió determinar el efecto de la administración del L-butionin sulfoximina sobre el contenido de glutatión, y los indicadores de daño oxidativo celular (malonildialdhehído, superóxido dismutasa, glutatión peroxidasa), a los siete días de la inyección intracerebroventricular, en la corteza frontal, el hipocampo y el cuerpo estriado, así como el efecto de la disminución del glutatión en el aprendizaje y la memoria, mediante la prueba de evitación pasiva. Los resultados sugirieron que el L-butionin sulfoximina induce un desbalance en la actividad enzimática antioxidante, que genera un daño en los componentes lipídicos celulares, y que existe un vínculo entre el daño oxidativo originado por la disminución de glutatión y la consolidación de la memoria.

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