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>Revistas >Cirugía y Cirujanos >Año 2013, No. 2


Ramírez-Torres N, Asbun-Bojalil J, Hernández-Valencia M
Embarazo y cáncer de mama
Cir Cir 2013; 81 (2)

Idioma: Español
Referencias bibliográficas: 46
Paginas: 98-107
Archivo PDF: 1053.43 Kb.


Texto completo




RESUMEN

Introducción: la asociación de cáncer de mama y embarazo no es común. El objetivo de esta investigación fue evaluar el embarazo, edad joven, etapa, tratamiento, pronóstico y mortalidad de las mujeres con cáncer de mama durante el embarazo.
Material y métodos: análisis retrospectivo de marzo 1992 a febrero 2009, se incluyeron 16 pacientes con cáncer de mama y embarazo. Se analizó: presentación clinicopatológica del tumor, tratamiento oncológico, evolución del embarazo. Del recién nacido se analizó: Apgar y peso. Se evaluo la mortalidad por grupo de edad y por intervalo de tiempo entre último embarazo y diagnóstico posterior de cáncer de mama y embarazo.
Resultados: características clínicohistológicas predominantes: etapa III (81.2%), T3-T4 (75%), N+ (93.7%), carcinoma ductal invasor (87.5%), grado histológico 2-3 (93.7%), receptor de estrogéno positivo (43.7%), receptor de progesterona positivo (25%), y receptor 2 del factor de crecimiento epidérmico humano positivo (31.2%).
Se aplicaron 27 ciclos de quimioterapia con: 5-fluorouracilo, epirrubicina y ciclofosfamida durante el segundo o tercer trimestre del embarazo, no hubo efectos adversos severos en las madres ni en los neonatos. El tiempo promedio de recurrencia de la enfermedad fue de 18.8 meses (limites 6-62 meses). La tasa de mortalidad en menores de 35 años fue 31.3% (p = 0.358). De las 16 pacientes, 7 habían muerto, y 9 estaban vivas sin evidencia de enfermedad.
Conclusiones: la etapa avanzada y número de ganglios afectados fueron más importantes que la edad, como los predictores de mal pronóstico para la recidiva y mortalidad de las pacientes jovenes con cáncer de mama y embarazo.


Palabras clave: mujer embarazada, cáncer de mama.


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>Revistas >Cirugía y Cirujanos >Año2013, No. 2
 

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