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2006, Número 1

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Rev Educ Bioquimica 2006; 25 (1)


Respuesta al problema bioquímico

Rodríguez ZJS

Idioma: Español
Referencias bibliográficas: 13
Paginas: 30-31
Archivo PDF: 48.17 Kb.


FRAGMENTO

En presencia de α-(2H)acetaldehído, la actividad de PAD disminuye más del 50%. Este efecto isotópico es indicativo de que el paso limitante de la reacción es la transferencia del hidruro.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Steinmetz CG, Xie P, Weiner H, Hurley TD (1997) Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion. Structure 5:701-11.

  2. Liu ZJ, Sun YJ, Rose J, Chung YJ, Hsiao CD, Chang WR, Kuo I, Perozich J, Lindahl R, Hempel J, Wang BC (1997) The first structure of an aldehyde dehydrogenase reveals novel interactions between NAD+ and the Rossmann fold. Nat Struct Biol 4:317-26.

  3. Moore SA, Baker HM, Blythe TJ, Kitson KE, Kitson TM, Baker EN (1998) Sheep liver cytosolic aldehyde dehydrogenase: the structure reveals the basis for the retinal specificity of class 1 aldehyde dehydrogenases. Structure 6:1541-51.

  4. Weiner H, Hu JH, Sanny CG (1976) Rate-limiting steps for the esterase and dehydrogenase reaction catalyzed by horse liver aldehyde dehydrogenase. J Biol Chem 251:3853-55.

  5. MacGibbon AK, Buckey PD, Blackwell LF (1977) Evidence for two-step binding of reduced nicotinamideadenine dinucleotide to aldehyde dehydrogenase. Biochem J 165:455-62.

  6. Wang XP, Weiner H (1995) Involvement of glutamate 268 in the active site of human liver mitochondrial (class 2) aldehyde dehydrogenase as probed by site-directed mutagenesis. Biochemistry 34:237-43.

  7. Mann CJ, Weiner H (1999) Differences in the roles of conserved glutamic acid residues in the active site of human class 3 and class 2 aldehyde dehydrogenases. Protein Sci 8:1922-29.

  8. Rout UK, Weiner H (1994) Involvement of serine 74 in the enzyme-coenzyme interaction of rat liver mitochondrial aldehyde dehydrogenase. Biochemistry 33: 8955-61.

  9. Ho KK, Allali-Hassani A, Hurley TD, Weiner H (2005) Differential effects of Mg2+ ions on the individual kinetic steps of human cytosolic and mitochondrial aldehyde dehydrogenases. Biochemistry 44:8022-29.

  10. Halton SP, Hill TK, Flavell MA, Stringfellow JM, Cooper RA (1997) 2-Phenylethylamine catabolism by Escherichia coli K-12: gene organization and expression. Microbiology 143: 513-18.

  11. Ferrandez A, Prieto MA, Garcia JL, Diaz E (1997) Molecular characterization of PadA, a phenylacetaldehyde dehydrogenase from Escherichia coli. FEBS Lett 406:23-7.

  12. Baldoma L, Aguilar J (1988) Metabolism of L-fucose and L-rhamnose in Escherichia coli: aerobic-anaerobic regulation of L-lactaldehyde dissimilation. J Bacteriol 170:416-21.

  13. Rodriguez-Zavala JS, Hassani A, Weiner H (2006) Characterization of E. coli tetrameric aldehyde dehydrogenases with atypical properties compared to other aldehyde dehydrogenases. Protein Sci. En Prensa.




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