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>Revistas >Evidencia Médica e Investigación en Salud >Año 2011, No. 1


Günther J, Pedernera-Astegiano E
E-cadherina: Pieza clave en la transformación neoplásica
Evid Med Invest Salud 2011; 4 (1)

Idioma: Español
Referencias bibliográficas: 53
Paginas: 15-20
Archivo PDF: 203.45 Kb.

[Texto completo - PDF]

RESUMEN

Las cadherinas son una superfamilia de glucoproteínas transmembranales que intervienen en la adhesión célula-célula. Las clásicas incluyen la E-cadherina y N-cadherina. La expresión y función de la E-cadherina es esencial para muchos procesos durante el desarrollo embrionario, como la polarización celular y diferenciación epitelial. Por otro lado se ha descubierto una importancia enorme en la tumorgénesis. La pérdida de la adhesión celular mediada por E-cadherina es un evento inicial de la transición epitelio-mesénquima (TEM), la cual se correlaciona con un incremento de invasión y metástasis en diversos cánceres humanos. Se ha demostrado que Snail es el promotor más importante de la TEM, inhibiendo la expresión de la E-cadherina y otros factores reguladores de la TEM. Por ello se considera a E-cadherina una pieza clave en la transformación neoplásica.


Palabras clave: Cadherinas, E-cadherina, Represores de E-cadherina, Transición Epitelio-Mesénquima, Cáncer.


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>Revistas >Evidencia Médica e Investigación en Salud >Año2011, No. 1
 

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