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>Revistas >Revista de Investigación Clínica >Año 2011, No. 2


Sauque-Reyna L, Salcedo-Parra MA, Sánchez-Vargas PR, Flores-Helguera JD, Badillo-Sánchez C, Reza-Albarrán A, Rodríguez-Morán M, Guerrero-Romero F
Densidad mineral ósea en pacientes con diabetes tipo 2
Rev Invest Clin 2011; 63 (2)

Idioma: Español
Referencias bibliográficas: 63
Paginas: 162-169
Archivo PDF: 72.03 Kb.


Texto completo




RESUMEN

Objetivo. Establecer si la presencia de diabetes (DM) tipo 2 se asocia a cambios en la densidad mineral ósea (DMO) de cuello femoral, cadera total y columna lumbar. Material y métodos. Estudio transversal, comparativo, en el que se incluyeron 450 mujeres mayores de 30 años de edad, 245 con DM tipo 2 y 205 sin DM, que constituyeron el grupo control. La edad fue criterio de pareamiento. La presencia de enfermedad articular degenerativa, artritis reumatoide, neoplasia, insuficiencia renal, hepatopatía crónica, ingesta de alcohol, tratamiento previo con medicamentos que modifican la DMO, Diabetes mellitus tipo1 y otras endocrinopatías, fueron criterios de exclusión. Resultados. En el grupo total, la presencia de menopausia se asoció con osteoporosis en cadera total (razón de momios -OR-4.2; IC95% 1.4-6.1), mientras que la DM tipo 2 mostró ser un factor de protección (OR 0.8; IC95% 0.4-0.9). En mujeres con premenopausia, la obesidad central y la adiposidad total se asociaron a la presencia de osteoporosis tanto en cadera (OR 1.9; IC95% 1.1-3.9 y OR 2.1; IC95% 1.2- 8.7) como en fémur (OR 2.1; IC95% 1.2-4.1 y OR 2.3; IC95% 1.3-7.1), mientras que la DM persistió como factor de protección (OR 0.7; IC95% 0.5-0.9 y OR 0.6; IC95% 0.4-0.9). En el análisis ajustado por IMC, circunferencia de cintura y adiposidad total, la DM tipo 2 persistió como factor de protección para osteoporosis en cadera (RM 0.8; IC95% 0.6-0.9) y fémur (RM 0.7; IC95% 0.5-0.9). Conclusiones. Los resultados de este estudio sugieren que la DM tipo 2 es un factor protector para osteoporosis.


Palabras clave: Diabetes tipo 2, Osteoporosis, Densidad mineral ósea, Riesgo.


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