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>Revistas >Revista de Sanidad Militar >Año 2012, No. 6


Romero-Torres JM, Almanza-Muñoz JJ, Asbun-Bojalil J, Reyes-Gutiérrez ME, Bravo-Valle J
Leucoaraiosis y su relación con los niveles de homocisteína en los pacientes con demencia
Rev Sanid Milit Mex 2012; 66 (6)

Idioma: Español
Referencias bibliográficas: 42
Paginas: 242-253
Archivo PDF: 67.67 Kb.


Texto completo




RESUMEN

Antecedentes. La deficiencia total o funcional de vitamina B12 se ha relacionado con la presencia de lesiones a pequeño vaso cerebral, conocido radiológicamente como leucoaraiosis.
Objetivo. Determinar la asociación existente entre la presencia de leucoaraiosis en los pacientes con demencia y los niveles elevados de homocisteína.
Método. Estudio observacional, prospectivo, transversal y analítico en 77 pacientes con diagnóstico de demencia Alzheimer, vascular o mixta, mediante protocolo de abordaje de un síndrome demencial con estudio de imagen (TAC o IRMN), en la clínica de psicogeriatría de la Unidad de Especialidades Médicas del ISSFAM. Se efectuó análisis descriptivo, correlacional y de regresión linear binaria.
Resultados. La presencia de niveles elevados de homocisteína se asocia con la presencia de leucoaraiosis en pacientes con demencia vascular o mixta por lo que se apoya el uso de este hallazgo por imagen como un indicador de deficiencia funcional de vitamina B12 en este grupo de pacientes.
Conclusiones. Estos resultados deben ser considerados a nivel clínico para valorar mediante criterio del médico tratante en el ofrecimiento al paciente de complemento vitamínico.


Palabras clave: Leucoaraiosis, homocisteina, demencia.


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