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2013, Número 3

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Rev Cubana Plant Med 2013; 18 (3)


Achyrocline satureioides (Lam.) DC. (marcela) reduce el daño cerebral en la isquemia focal permanente en ratas

Rivera MF, Tejera CD, Abin CJA, Prunell SG, Martínez BM, Dajas MF

Idioma: Ingles.
Referencias bibliográficas: 55
Paginas: 445-460
Archivo PDF: 454.97 Kb.


RESUMEN

Introducción: Achyrocline satureioides es una planta que ha sido ampliamente utilizada en la medicina popular y los estudios experimentales confirman sus efectos antioxidantes y antiinflamatorios, atribuibles a la presencia de flavonoides, principalmente quercetina.
Objetivos: evaluar los efectos neuroprotectores de la pre-administración oral crónica a ratas con una decocción de Achyrocline satureioides 2 %.
Métodos: para la decocción se utilizaron flores secas de Achyrocline satureioides. Se cuantificaron, diariamente, el consumo de alimentos, la decocción y el agua; y cada semana, la ganancia de peso. El contenido de quercetina en la decocción y en el plasma de las ratas se evaluó utilizando la técnica de cromatografía líquida de alta resolución. El daño cerebral se cuantificó con una sal de tetrazolio y antes se realizó una prueba de comportamiento. Se utilizaron la tinción de Nissl y el fluoro Jade.
Resultados: el pretratamiento con Achyrocline satureioides en todos los grupos revirtió el déficit funcional, y la decocción durante 21 días también decreció de modo significativo el volumen del infarto. La tinción de Nissl mostró alto porcentaje de población neuronal conservada y el fluoro Jade presentó un decrecimiento en las neuronas en degeneración.
Conclusiones: los niveles de quercetina en la decocción y el plasma de las ratas podrían explicar los beneficios preventivos de Achyrocline satureioides, debido a las propiedades antioxidantes y antiinflamatorias descritas para este flavonoide.


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