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>Revistas >Gaceta Médica de México >Año 2003, No. 5

Elinos-Báez CE, Maldonado V, Meléndez ZJ
Caspasas: moléculas inductoras de apoptosis
Gac Med Mex 2003; 139 (5)

Idioma: Español
Referencias bibliográficas: 84
Paginas: 493-499
Archivo PDF: 91.62 Kb.

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Las caspasas son proteínas clave en la transducción y ejecución de la señal apoptótica inducida por una diversidad de estímulos. Se encuentran en la célula como precursores inactivos que necesitan ser cortados para iniciar su actividad. Existen dos grandes grupos de caspasas, las denominadas iniciadoras y las ejecutoras. Las caspasas iniciadoras son activadas por autoproteólisis cuando son translocadas a compartimientos específicos o mediante adaptadores/activadores. Las caspasas ejecutoras son activadas mediante el corte específico mediado por las caspasas iniciadoras. Estas proteasas son las encargadas de los cortes finales de sustratos que provocan la morfología típica de la apoptosis. Entre éstos se encuentran proteínas de señal, de reparación de ADN, estructurales, factores de transcripción, etc. Las caspasas representan un nuevo paradigma de la transducción de la señal y se encuentran implicadas en un gran número de procesos fisiológicos y patológicos. En un futuro podrían servir como marcadores de procesos patológicos y como blanco de nuevas terapias.

Palabras clave: Apoptosis, caspasas, IAP.


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>Revistas >Gaceta Médica de México >Año2003, No. 5

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