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>Revistas >Revista de la Facultad de Medicina UNAM >Año 2015, No. 4


Maldonado MMG, Pereyra MMA, Zenteno GEA
Estructura y función de la alfa-fetoproteína
Rev Fac Med UNAM 2015; 58 (4)

Idioma: Español
Referencias bibliográficas: 40
Paginas: 5-13
Archivo PDF: 226.65 Kb.


Texto completo




RESUMEN

La alfa-fetoproteína es una glicoproteína que ha sido considerada como un marcador oncofetal, cuya aplicación se ha demostrado en el diagnóstico y pronóstico de enfermedades tumorales como el carcinoma hepatocelular, y también es de gran utilidad para identificar malformaciones fetales relacionadas con fallas del cierre del tubo neural y anencefalia. Diversos trabajos establecen una interesante relación entre la estructura y la función de esta proteína que permite regular la respuesta inmune de la madre y que podría participar en los eventos que evitan el rechazo del embrión. En esta revisión se identifican algunos aspectos moleculares de la alfa-fetoproteína que abren interesantes perspectivas para entender mejor su participación en el desarrollo de alteraciones tumorales.


Palabras clave: Alfa-fetoproteína, hepatoma celular, lectinas.


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