Cavallo AF, Mendoza AG, Roldán AB

Idioma: Español
Referencias bibliográficas: 13
Paginas:
Archivo PDF: 112.70 Kb.

RESUMEN

La enfermedad de Graves es un desorden autoinmune que constituye la principal causa de hipertiroidismo en niños; usualmente se manifiesta con bocio difuso, signos de oftalmopatía bilateral y la alteración bioquímica en las pruebas de función tiroidea. En ocasiones, los síntomas iniciales se presentan con manifestaciones psiquiátricas, lo que llega a ser un reto en el diagnóstico diferencial, ya sea del trastorno tiroideo primario o un trastorno psiquiátrico. Debido a la poca frecuencia con que esta manifestación de la enfermedad de graves se presenta en pediatría se expone aquí el caso de hipertiroidismo y psicosis aguda en un paciente pediátrico.

REFERENCIAS (EN ESTE ARTÍCULO)

1. Bunevicius, R., Prange, ArthurJ. Psychiatric Manifestations of Graves´Hyperthyroidism: Pathophysiology and Treatment Options. Therapy In Practice. CNS Drugs 2006; 20 (11), 897-909.

2. Weetman AP. Graves´disease. N Engl J Med 2000; 343: 1236-48.

3. Stern, Robert A., et al. A Survey Study of Neuropsychiatric Complaints in Patients with Graves´ Disease. The Journal of Neuropsychiatry and Clinical Neurosciences. 1996; 8:181-185.

4. Marangell B., Callahan AM. Mood disorders and the thyroid axis. Curr Opinion in Psychiatry 1998; 11: 67-70.

5. Musselman DL, Nemerott CB. Depression and endocrine disorders. Focus on the thyroid and adrenal system. Br J Psychiatry (Suppl) 1998; 30: 123- 128.

6. Cleare AK, McGergor A, O´Keane V. Neuroendocrine evidence for an association between hypothyroidism, reduced central 5-HT activity and depression. ClinEndocrinol 1995; 43: 713-719.

7. Rivkees SA, Sklar C, Freemark M. Clinical review 99: The management of Graves´disease in children, with special emphasis on radioiodine treatment. J ClinEndocrinolMetab 1998; 83;3767.

8. Rivkees SA, Szarfman A. Dissimilar hepatotoxicity profiles of propylthiouracil and methimazole in children. J ClinEndocrinolMetab 2010; 95;3260.

9. Pao M, Lohman C, Gracey D, et al. Visual, tactile, and phobic hallucinations: recognition and management in the emergency department. Pediatr Emerg Care. 2004;20:30-34.

10. Kanwae, Ajit, S. Sidhu. Hallucinations in children: Diagnostic and treatment strategies. Current Psychiatry Vol.9, No. 10, October 2010.

11. Varese, Fillipo, et al. Childhood Adversities Increase the Risk of Psychosis: A Meta-analysis of Patient- Control, Prospective- and Cross-sectional Cohort Studies. Schizophrenia Bulletin Advance Access. March 29, 2012.

12. Read J, Bentall R, Dillon J, eds. Models of Madness: Psychological, Social and Biological Approaches to Psychosis. 2nd ed. London: Routledge. In press. 2006.

13. Barrio R, López-Capapé M, Martínez- Badás I, et al. Graves´disease in children and adolescents: response to long-term treatment. ActaPaediatr 2005; 94:1583.