Entrar/Registro  
INICIO ENGLISH
 
NCT Neumología y Cirugía de Tórax
   
MENÚ

Contenido por año, Vol. y Num.

Índice de este artículo

Información General

Instrucciones para Autores

Mensajes al Editor

Directorio






>Revistas >NCT Neumología y Cirugía de Tórax >Año 2015, No. 3


Machado-Villarroel L, Acosta-Loya JA, Orozco-Andrade I, Bravo-Rodríguez G, Dimakis-Ramírez DA
Determinación del interferón-gamma en tuberculosis: Principios básicos y utilidad
Neumol Cir Torax 2015; 74 (3)

Idioma: Español
Referencias bibliográficas: 42
Paginas: 197-206
Archivo PDF: 300.94 Kb.


Texto completo




RESUMEN

La tuberculosis es una enfermedad transmisible distribuida globalmente con tasas de morbimortalidad elevadas. Resulta fundamental establecer un diagnóstico y tratamiento oportunos de la infección por tuberculosis. La reducción de tuberculosis latente reduce el riesgo de progresión a tuberculosis activa. La prueba cutánea de tuberculina es el método estándar de detección de infección por tuberculosis latente, empero presenta limitaciones en su desempeño, sensibilidad y especificidad; principalmente en individuos inmunocomprometidos y/o previamente vacunados con bacilo Calmette-Guérin. La prueba IGRA (del inglés interferon-gamma release assay, ensayo de liberación de interferón-gamma) fue diseñada para complementar el diagnóstico de infección latente por tuberculosis e incrementar la sensibilidad y especificidad, al cuantificar el interferón-gamma producido por linfocitos-T sensibilizados en respuesta al contacto con antígenos específicos de Mycobacterium tuberculosis. El IGRA aún es incapaz de discriminar una infección previa o actual por Mycobacterium tuberculosis, tampoco puede diferenciar entre infección latente por tuberculosis y tuberculosis activa. Existen dos pruebas IGRA disponibles comercialmente: QuantiFERON®-TB Gold In-Tube y T-SPOT®TB. El desempeño es superior en individuos inmunocompetentes › 5 años de edad. Sin embargo, la eficacia clínica resulta afectada en individuos inmunodeprimidos, debido a una síntesis reducida y fluctuante de interferón-gamma en dicho grupo de pacientes. Factores como la inmunosupresión contribuyen a obtener resultados indeterminados, lo cual debe considerarse al momento de interpretar la prueba


Palabras clave: Ensayos de liberación de interferón-gamma, interferón-gamma, linfocitos-T, tuberculosis latente.


REFERENCIAS

  1. Nenadić N, Kirin BK, Letoja IZ, Plavec D, Topić RZ, Dodig S. Serial interferon-γ release assay in children with latent tuberculosis infection and children with tuberculosis. Pediatr Pulmonol 2012;47(4):401-408. doi: 10.1002/ppul.21555.

  2. Delgado-Sánchez G, García-García L, Castellanos-Joya M, et al. Association of pulmonary tuberculosis and diabetes in Mexico: Analysis of the National Tuberculosis Registry 2000-2012. PLoS One 2015;10(6):e0129312. doi: 10.1371/journal.pone.0129312.

  3. Demlow SE, Oh P, Barry PM. Increased risk of tuberculosis among foreign-born persons with diabetes in California, 2010-2012. BMC Public Health 2015;15:263-270. doi: 10.1186/s12889-015-1600-1.

  4. Bretscher PA. On the mechanism determining the TH1/TH2 phenotype of an immune response, and its pertinence to strategies for the prevention, and treatment, of certain infectious diseases. Scand J Immunol 2014;79(6):361-376. doi: 10.1111/sji.12175.

  5. Little KM, Pai M, Dowdy DW. Costs and consequences of using interferon-γ release assays for the diagnosis of active tuberculosis in India. PLoS One 2015;10(4):e0124525. doi: 10.1371/journal.pone.0124525

  6. Shakak AO, Khalil EA, Musa AM, et al.; Tuberculosis Research Group/Sudan. Prevalence of latent tuberculosis infection in Sudan: a case-control study comparing interferon-gamma release assay and tuberculin skin test. BMC Public Health 2013;13:1128-1138. doi: 10.1186/1471-2458-13-1128.

  7. Pollock L, Roy RB, Kampmann B. How to use: interferon-γ release assays for tuberculosis. Arch Dis Child 2013;98:99-105.

  8. Sester M, van Leth F, Bruchfeld J, et al.; TBNET. Risk assessment of tuberculosis in immunocompromised patients: a TBNET study. Am J Respir Crit Care Med 2014;190(10):1168-1176. doi: 10.1164/rccm.201405-0967OC.

  9. Chee CB, Sester M, Zhang W, Lange C. Diagnosis and treatment of latent infection with Mycobacterium tuberculosis. Respirology 2013;18(2):205-216. doi: 10.1111/resp.12002.

  10. Abubakar I, Stagg HR, Whitworth H, Lalvani A. How should I interpret an interferon-gamma release assay result for tuberculosis infection? Thorax 2013;68(3):298-301. doi: 10.1136/thoraxjnl-2013-203247.

  11. Bendayan D, Hendler A, Litman K, Polansky V. The role of interferon-gamma release assays in the diagnosis of active tuberculosis. Isr Med Assoc J 2012;14(2):107-110.

  12. Park H, Shin JA, Kim HJ, Ahn CM, Chang YS. Whole blood interferon-γ release assay is insufficient for the diagnosis of sputum smear negative pulmonary tuberculosis. Yonsei Med J 2014;55(3):725-731. doi: 10.3349/ymj.2014.55.3.725.

  13. Papay P, Eser A, Winkler S, et al. Predictors of indeterminate IFN-γ release assay in screening for latent TB in inflammatory bowel diseases. Eur J Clin Invest 2011;41(10):1071-1076. doi: 10.1111/j.1365-2362.2011.02502.x.

  14. Denkinger CM, Dheda K, Pai M. Guidelines on interferon-γ release assays for tuberculosis infection: concordance, discordance or confusion? Clin Microbiol Infect 2011;17(6):806-814. doi: 10.1111/j.1469-0691.2011.03555.x.

  15. de Souza-Galvão ML, Latorre I, Altet-Gómez N, et al. Correlation between tuberculin skin test and IGRAs with risk factors for the spread of infection in close contacts with sputum smear positive in pulmonary tuberculosis. BMC Infect Dis 2014;14:258-276. doi: 10.1186/1471-2334-14-258.

  16. Pullar ND, Steinum H, Bruun JN, Dyrhol-Riise AM. HIV patients with latent tuberculosis living in a low-endemic country do not develop active disease during a 2 year follow-up; a Norwegian prospective multicenter study. BMC Infect Dis 2014;14:667-683. doi: 10.1186/s12879-014-0667-0.

  17. Singh M, Saini AG, Anil N, Aggarwal A. Latent tuberculosis in children: diagnosis and management. Indian J Pediatr 2011;78(4):464-468. doi: 10.1007/s12098-010-0295-7.

  18. Dagnew AF, Hussein J, Abebe M, et al. Diagnosis of latent tuberculosis infection in healthy young adults in a country with high tuberculosis burden and BCG vaccination at birth. BMC Research Notes 2012;5:415-421. doi: 10.1186/1756-0500-5-415.

  19. Frieri M, Settipane RA. What every physician should know about rapid diagnosis of Mycobacterium tuberculosis infection in children using interferon-gamma release assays. Allergy Asthma Proc 2012;33(3):215-216. doi: 10.2500/aap.2012.33.3580.

  20. Sollai S, Galli L, de Martino M, Chiappini E. Systematic review and meta-analysis on the utility of interferon-gamma release assays for the diagnosis of Mycobacterium tuberculosis infection in children: a 2013 update. BMC Infect Dis 2014;14 Suppl 1:S6. doi: 10.1186/1471-2334-14-S1-S6.

  21. Kamiya H, Ikushima S, Kondo K, et al. Diagnostic performance of interferon-gamma release assays in elderly populations in comparison with younger populations. J Infect Chemother 2013;19(2):217-222. doi: 10.1007/s10156-012-0480-x.

  22. Carvalho AC, Schumacher RF, Bigoni S, et al. Contact investigation based on serial interferon-gamma release assays (IGRA) in children from the hematology-oncology ward after exposure to a patient with pulmonary tuberculosis. Infection 2013;41(4):827-831. doi: 10.1007/s15010-013-0450-y.

  23. Diel R, Loddenkemper R, Niemann S, Meywald-Walter K, Nienhaus A. Negative and positive predictive value of a whole-blood interferon-γ release assay for developing active tuberculosis: an update. Am J Respir Crit Care Med 2011;183(1):88-95. doi: 10.1164/rccm.201006-0974OC.

  24. Lee SW, Lee CT, Yim JJ. Serial interferon-gamma release assays during treatment of active tuberculosis in young adults. BMC Infect Dis 2010;10:300-307. doi: 10.1186/1471-2334-10-300.

  25. Redelman-Sidi G, Sepkowitz KA. IFN-γ release assays in the diagnosis of latent tuberculosis infection among immunocompromised adults. Am J Respir Crit Care Med 2013;188(4):422-431. doi: 10.1164/rccm.201209-1621CI.

  26. Lahey T, Czechura T, Crabtree S, et al. Greater preexisting interferon-γ responses to mycobacterial antigens and lower bacillary load during HIV-associated tuberculosis. J Infect Dis 2013;208(10):1629-1633. doi: 10.1093/infdis/jit396.

  27. Elzi L, Steffen I, Furrer H, et al. Improved sensitivity of an interferon-gamma release assay (T-SPOT.TBTM) in combination with tuberculin skin test for the diagnosis of latent tuberculosis in the presence of HIV co-infection. BMC Infect Dis 2011;11:319-327. doi: 10.1186/1471-2334-11-319.

  28. Aabye MG, Hermansen TS, Ruhwald M, et al. Negative effect of smoking on the performance of the QuantiFERON®-TB Gold In-Tube test. BMC Infect Dis 2012;12:379-384. doi: 10.1186/1471-2334-12-379.

  29. Banfield S, Pascoe E, Thambiran A, Siafarikas A, Burgner D. Factors associated with the performance of a blood-based interferon-γ release assay in diagnosing tuberculosis. PLoS One 2012;7(6):e38556. doi: 10.1371/journal.pone.0038556

  30. Hang NT, Lien LT, Kobayashi N, et al. Analysis of factors lowering sensitivity of interferon-γ release assay for tuberculosis. PLoS One 2011;6(8):e23806. doi: 10.1371/journal.pone.0023806.

  31. Fujikawa A, Fujii T, Mimura S, et al. Tuberculosis contact investigation using interferon-gamma release assay with chest x-ray and computed tomography. PLoS One 2014;9(1):e85612. doi: 10.1371/journal.pone.0085612.

  32. Jurčev-Savičević A, Katalinić-Janković V, Miše K, Gudelj I. The role of interferon-gamma release assay in tuberculosis control. Arh Hig Rada Toksikol 2012;63(81):49-59. doi: 10.2478/10004-1254-63-2012-2134.

  33. Lienhardt C, Fielding K, Hane AA, et al. Evaluation of the prognostic value of IFN-γ release assay and tuberculin skin test in household contacts of infectious tuberculosis cases in Senegal. PLoS One 2010;5(5):e10508. doi: 10.1371/journal.pone.0010508.

  34. Lee SW, Lee SH, Yim JJ. Serial interferon-gamma release assays after chemoprophylaxis in a tuberculosis outbreak cohort. Infection 2012;40(4):431-435. doi: 10.1007/s15010-012-0265-2.

  35. Feng Y, Diao N, Shao L, et al. Interferon-gamma release assay performance in pulmonary and extrapulmonary tuberculosis. PLoS One 2012;7(3):e32652. doi: 10.1371/journal.pone.0032652.

  36. Savaj S, Savoj J, Ranjbar M, Sabzghabaei F. Interferon-gamma release assay agreement with tuberculin skin test in pretransplant screening for latent tuberculosis in a high-prevalence country. Iran J Kidney Dis 2014;8(4):329-332.

  37. Taki-Eddin L, Monem F. Utility of an interferon-gamma release assay as a potential diagnostic aid for active pulmonary tuberculosis. J Infect Dev Ctries 2012;6(1):67-72.

  38. Schablon A, Diel R, Diner G, et al. Specificity of a whole blood IGRA in German nursing students. BMC Infect Dis 2011;11:245-251. doi: 10.1186/1471-2334-11-245.

  39. Fan L, Chen Z, Hao XH, Hu ZY, Xiao HP. Interferon-gamma release assays for the diagnosis of extrapulmonary tuberculosis: a systematic review and meta-analysis. FEMS Immunol Med Microbiol 2012;65(3):456-466. doi: 10.1111/j.1574-695X.2012.00972.x.

  40. Elfrink F, van den Hoek A, Mensen ME, Sonder GJ. Screening travellers to high-endemic countries for infection with Mycobacterium tuberculosis using interferon-gamma release assay; a prospective study. BMC Infect Dis 2014;14:515-520. doi: 10.1186/1471-2334-14-515.

  41. Tabarsi P, Yousefzadeh A, Najafizadeh K, et al. Performance of QuantiFERON®-TB Gold In-Tube test in detecting latent tuberculosis infection in brain-dead organ donors in Iran: a brief report. Saudi J Kidney Dis Transpl 2014;25(6):1240-1243.

  42. Mardani M, Farshidpour M, Nekoonam M, et al. Performance of QuantiFERON®-TB Gold In-Tube test compared with the tuberculin skin test for detecting latent tuberculosis infection in lung and heart transplant candidates. Exp Clin Transplant 2014;12(2):129-132.



>Revistas >NCT Neumología y Cirugía de Tórax >Año2015, No. 3
 

· Indice de Publicaciones 
· ligas de Interes 






       
Derechos Resevados 2019