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2003, Número 3

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Cir Cir 2003; 71 (3)


Inmunidad innata, receptores Toll y sepsis

Carrillo-Esper R

Idioma: Español
Referencias bibliográficas: 89
Paginas: 252-258
Archivo PDF: 109.35 Kb.


RESUMEN

La respuesta inmune innata es la primera línea de defensa contra la infección. Los receptores semejantes a Toll (TLRs: Toll-like receptors) reconocen al lipopolisacárido bacteriano y otros patrones moleculares asociados a patógenos (PAPMs: Pathogen Associated Molecular Patterns). Los eventos moleculares intracelulares iniciados por la interacción entre TLRs y su PAPMs específicos desencadenan respuesta inflamatoria sistémica. La sepsis y el choque séptico son el resultado de una respuesta inflamatoria exagerada secundaria a disregulación de la inmunidad innata.


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