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>Revistas >Ginecología y Obstetricia de México >Año 2005, No. 07


Hernández VM, Zárate A
Conceptos recientes en la etiopatogenia de la diabetes gestacional
Ginecol Obstet Mex 2005; 73 (07)

Idioma: Español
Referencias bibliográficas: 36
Paginas: 371-377
Archivo PDF: 63.18 Kb.

[Texto completo - PDF]

RESUMEN

Los cambios en la acción de la insulina condicionan la adaptación del metabolismo materno para favorecer la disposición de los nutrientes que requiere el feto en su desarrollo; de esta forma se establece un estado de resistencia a la insulina que genera mayor producción de insulina a fin de compensar dicha resistencia. Sin embargo, las células-β del páncreas podrían estar lesionadas y ser insuficientes para compensar esta demanda. Las causas a las que se atribuye el desencadenamiento de la diabetes gestacional son: concentración elevada de las hormonas placentarias; péptidos producidos por el tejido adiposo, a los cuales se les ha asignado un factor de predicción para el desencadenamiento de resistencia a la insulina; efecto adverso de la mala nutrición en la vida intrauterina; autoinmunidad que se activa por el consumo de algunos nutrientes en la vida neonatal; procesos virales que aparecen en la niñez. Esto puede lesionar los islotes pancreáticos y volverlos deficientes para reaccionar a una sobrecarga metabólica como el embarazo.


Palabras clave: resistencia a la insulina, diabetes gestacional.


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>Revistas >Ginecología y Obstetricia de México >Año2005, No. 07
 

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