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Instituto Nacional de Neurología y Neurocirugía

2005, Número 3

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Arch Neurocien 2005; 10 (3)


Efectos favorables de la piridoxina y el ácido fólico administredosa shr-sp

Perez SC, Vianna LM

Idioma: Ingles.
Referencias bibliográficas: 24
Paginas: 146-149
Archivo PDF: 60.83 Kb.


RESUMEN

La homocisteina se ha asociado a la enfermedad vascular cerebral (EVC), que realza el interés para la investigación sobre el papel de las vitaminas implicadas en su metabolismo. Ratas Spontaniously Hypertensive Stronke-Prone Rats SHRSP fueron tratados con piridoxina y el ácido fólico en las dosis correspon-dientes a cinco, diez y veinte veces sus necesidades alimenticias. La presión arterial sistólica y los parámetros generales fueron analizados y comparados al grupo de control. Los correspondientes de las dosis a 10 y 20 veces RDA promovieron un efecto hipotenso, pero los concernientes a las dosis a 5 veces, no. Los animales tratados en 190 días de la edad presentaron una reducción significativa de la presión arterial sistólica cuando está comparado al grupo de control. Los ani-males bajo tratamiento no presentaron las muestras de enfermedad cerebral detectadas naturalmente en ese acoplamiento. Nuestros resultados sugieren que las vitaminas B6 y B9 podrían ser beneficiosas para la terapia preventiva del EVC.


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