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2016, Número 1

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Revista Cubana de Ortopedia y Traumatología 2016; 30 (1)


Tratamiento de tumores de células gigantes

Aguilar EA, López SJ, Lillo AM, Peguero BA

Idioma: Español
Referencias bibliográficas: 25
Paginas: 1-7
Archivo PDF: 103.51 Kb.


RESUMEN

Introducción: el tumor de células gigantes se presenta en adultos jóvenes, y su capacidad metastásica obliga a realizar un tratamiento quirúrgico, aunque su tasa de recurrencias hace que no haya consenso respecto a la conducta terapéutica.
Método: 23 pacientes fueron intervenidos en el periodo de 1996 a 2012 en el hospital universitario "Miguel Servet", a los que se les realizó un seguimiento medio de 8,9 años.
Resultados: el resultado funcional fue satisfactorio en todos los casos, pues todos los pacientes pudieron reanudar su actividad física habitual. Se detectaron 6 pacientes con recurrencias que fueron tratadas quirúrgicamente; estos pacientes también tuvieron una recuperación total. Un paciente falleció a causa de metástasis pulmonares.
Conclusiones: el tratamiento quirúrgico es el más indicado en tumores de células gigantes, se lograron buenos resultados tanto en el tratamiento del tumor primario como de las recidivas.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Liede A, Bach BA, Stryker S, Hernandez RK, Sobocki P, Bennett B, et al. Regional variation and challenges in estimating the incidence of giant cell tumor of bone. J Bone Joint Surg Am. 2014 Dec 3;96(23):1999-2007.

  2. Jiang N, Qin CH, Tan CX, Wen SF, Ma YF, Dong F, et al. A retrospective analysis of 140 patients with giant cell tumor in the extremity: a multicenter study based on four hospitals in South China. Cancer Epidemiol. 2013 Jun;37(3):294-9.

  3. Niu X, Xu H, Inwards CY, Li Y, Ding Y, Letson GD, et al. Primary Bone Tumors: Epidemiologic comparison of 9 200 patients treated at Beijing Ji Shui Tan Hospital, Beijing, China, with 10 165 patients at Mayo Clinic, Rochester, Minnesota. Arch Pathol Lab Med. 2015 Sep;139(9):1149-55.

  4. Zhang Z, Xu J, Yao Y, Chu S, Cheng H, Chen D, et al. Giant cell tumors of the skull: a series of 18 cases and review of the literature. J Neurooncol. 2013 Dec;115(3):437-44.

  5. Pereira HM, Marchiori E, Severo AJ. Magnetic resonance imaging aspects of giantcell tumours of bone. Med Imaging Radiat Oncol. 2014 Dec;58(6):674-8.

  6. Chan CM, Adler Z, Reith JD, Gibbs CP. Risk factors for pulmonary metastases from giant cell tumor of bone. J Bone Joint Surg Am. 2015 Mar 4;97(5):420-8.

  7. Cheng DD, Hu T, Zhang HZ, Huang J, Yang QC. Factors affecting the recurrence of giant cell tumor of bone after surgery: A clinicopathological study of 80 cases from a single center. Cell Physiol Biochem. 2015;36(5):1961-70.

  8. Bergovec M, Petkovi M, Smerdelj M, Seiwerth S, Brki· L, Robert K, et al. Giant cell tumor of bone: results and treatment complications. Acta Med Croatica. 2014 Dec;68(4-5):405-10.

  9. Raskin KA, Schwab JH, Mankin HJ, Springfield DS, Hornicek FJJ. Giant cell tumor of bone. Am Acad Orthop Surg. 2013 Feb;21(2):118-26.

  10. Wysocki RW, Soni E, Virkus WW, Scarborough MT, Leurgans SE, Gitelis S. Is intralesional treatment of giant cell tumor of the distal radius comparable to resection with respect to local control and functional outcome? Clin Orthop Relat Res. 2015 Feb;473(2):706-15.

  11. Kundu ZS, Gupta V, Sangwan SS, Rana P. Curettage of benign bone tumors and tumor like lesions: A retrospective analysis. Indian J Orthop. 2013 May;47(3):295-301.

  12. Chakarun CJ, Forrester DM, Gottsegen CJ, Patel DB, White EA, Matcuk GR Jr. Giant cell tumor of bone: review, mimics, and new developments in treatment. Radiographics. 2013 Jan-Feb;33(1):197-211.

  13. Rajani R, Schaefer L, Scarborough MT, Gibbs CP. Giant cell tumors of the foot and ankle bones: high recurrence rates after surgical treatment. J Foot Ankle Surg. Nov- Dec. 2015;54(6):1141-5.

  14. Loquercio G, Di Costanzo G, Fazioli F, Gallo M, De Chiara A, Lervolino V, et al. Autologous platelet gel improves bone reconstruction of large defects in patients with bone giant cell tumors. In Vivo. Sept-Oct. 2015;29(5):533-40.

  15. Gouin F, Dumaine V. French Sarcoma and Bone Tumor Study Groups GSF-GETO. Local recurrence after curettage treatment of giant cell tumors in peripheral bones: retrospective study by the GSF-GETO (French Sarcoma and Bone Tumor Study Groups). Orthop Traumatol Surg Res. 2013 Oct;99(6 Suppl):S313-8.

  16. Zhang S, Xu MT, Wang XQ, Wang JJ. Functional outcome of en bloc excision and custom prosthetic replacement for giant cell tumor of the distal radius. J Orthop Sci. 2015 Nov;20(6):1090-7.

  17. Hara H, Akisue T, Kawamoto T, Onishi Y, Fujioka H, Nishida K, et al. Reconstruction of the midfoot using a free vascularized fibular graft after en bloc excision for giant cell tumor of the tarsal bones: A case report. J Foot Ankle Surg. 2015 Jul 24. pii: S1067-2516(15)00183-0. doi: 10.1053/j.jfas.2015.04.020. [Epub ahead of print]

  18. AlSulaimani SA, Turcotte RE. Canadian Orthopaedic Oncology Society (CANOOS) collaborators. Iterative curettage is associated with local control in giant cell tumors involving the distal tibia. Clin Orthop Relat Res. 2013 Aug;471(8):2668-74.

  19. Ma Y, Xu W, Yin H, Huang Q, Liu T, Yang X, et al. Therapeutic radiotherapy for giant cell tumor of the spine: a systemic review. Eur Spine J. 2015 Aug;24(8):1754- 60. doi: 10.1007/s00586-015-3834-0. Epub 2015 May 6.

  20. Shi W, Indelicato DJ, Reith J, Smith KB, Morris CG, Scarborough MT, et al. Radiotherapy in the management of giant cell tumor of bone. Am J Clin Oncol. 2013 Oct;36(5):505-8. doi: 10.1097/COC.0b013e3182568fb6.

  21. Skubitz KM. Giant cell tumor of bone: current treatment options. Curr Treat Options Oncol. 2014 Sep;15(3):507-18.

  22. Singh AS, Chawla NS, Chawla SP. Giant-cell tumor of bone: treatment options and role of denosumab. Biologics. 2015 Jul;14(9):69-74.

  23. Vaishya R, Agarwal AK, Vijay V. 'Salvage treatment' of aggressive giant cell tumor of bones with denosumab. Cureus. 2015 Jul 30;7(7):e291.

  24. Brodowicz T, Hemetsberger M, Windhager R. Denosumab for the treatment of giant cell tumor of the bone. Future Oncol. 2015 Jul;11(13):1881-94.

  25. Lim SY, Rastalsky N, Choy E, Bolster MB. Tibial stress reaction presenting as bilateral shin pain in a man taking denosumab for giant cell tumor of the bone. Bone. 2015 Jun;25(81):31-5.




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