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>Revistas >Revista de la Asociación Dental Mexicana >Año 2016, No. 5


Martínez RJI, Xibillé FDX, Montiel HJL
Posible papel de Porphyromonas gingivalis en el desarrollo de la artritis reumatoide
Rev ADM 2016; 73 (5)

Idioma: Español
Referencias bibliográficas: 73
Paginas: 235-240
Archivo PDF: 257.38 Kb.


Texto completo




RESUMEN

Varios estudios han sugerido una asociación entre la periodontitis severa, la prevalencia de la bacteria Porphyromonas gingivalis y el desarrollo de artritis reumatoide. Como fundamento de esta relación, se ha observado que esta bacteria secreta una enzima, peptidil-arginina deiminasa, que es capaz de citrulinar proteínas del hospedero y así favorecer una respuesta autoinmune. Sin embargo, debido a la heterogeneidad de diseños experimentales, selección de pacientes y valoración de los desenlaces, los resultados no han mostrado la reproducibilidad deseada. Asimismo, observaciones recientes apuntan a que la actividad enzimática podría ser generada por otras especies bacterianas, lo que hace más compleja su relación. Sin embargo, por otro lado, algunos estudios sugieren que el tratamiento periodontal puede limitar el desarrollo de la artritis reumatoide.


Palabras clave: Periodontitis, P. gingivalis, artritis reumatoide, peptidil-arginina deiminasa bacteriana.


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