2000, Número 2
Referencias bibliográficas: 38
Archivo PDF: 62.15 Kb.
RESUMENMore than two decades ago, enrofloxacin, a fluoroquinolone, was first used in Mexico and Latin America. This agent was and still is, regarded as the most potent antibacterial agent available in veterinary medicine. At first, it was dosed at a rate of 5 mg/kg/day and it was retailed in a 5% solution. Today the dose has been increased to 10 mg/kg/day, and it is commercially available in 10% solutions. This trend indicates a tendency towards increasing bacterial resistance, which coincides with vast amount, and unpublished communications of lack of clinical trials and reports of demonstrated bacterial resistance. Additionally, the availability in the market pharmaceutical analogs of uncontrolled quality, plus the careless use of the drug under field conditions may be more relevant to the perceived clinical failure than a hypothetical bacterial resistance surge. In this paper, an overview on the use and abuse of enrofloxacin is presented. Considering that understanding enrofloxacin is the most potent antibacterial so far found for veterinary medicine, authors regarded as important present the current status of the use of enrofloxacin in the poultry industry. The main pharmacological features of this drug are presented within the context of its use in Mexico and many Latin American settings, hoping with this, to improve the way in which enrofloxacin is given in daily clinical practice.
REFERENCIAS (EN ESTE ARTÍCULO)
Garcia-Ovando H, Luders C, Gorla N, Errecalde C, Prieto G. Intravenous pharmacokinetics of enrofloxacin and ciprofloxacin in broiler chickens. Proceedings of the 7th European Association for Veterinary Pharmacology and Toxicology International Congress; 1997 July 6-10. Madrid, Spain. Jvet Pharmacol Ther. 1997;20(suppl):203-204.