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Academia Mexicana de Neurología, A.C.

2017, Número 4

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Rev Mex Neuroci 2017; 18 (4)


Síndrome de la persona rígida. Caso clínico y revisión de la literatura

Cabrera EES, Enríquez CG

Idioma: Español
Referencias bibliográficas: 41
Paginas: 86-94
Archivo PDF: 284.35 Kb.


RESUMEN

Introducción: El Síndrome de la Persona Rígida (SPR) es una patología neurológica inmunomediada caracterizada por la rigidez muscular axial y periférica, la presencia de espasmos musculares dolorosos y trastornos psiquiátricos como fobias y ansiedad.
Reporte de caso: Presentamos el caso de una mujer de 71 años de edad que inicia con caídas recurrentes y sensación de rigidez en miembros pélvicos. Se solicitó la determinación de anticuerpos antiglutamato descarboxilasa (anti-GAD), los cuales se reportaron con títulos de 148.58 UI/mL (Valor de referencia: ‹10 UI/mL) y los estudios en búsqueda de neoplasias fueron negativos. Se diagnosticó SPR y se hospitalizó para administración de inmunoglobulina. Actualmente la paciente presenta rigidez generalizada, persistencia de los espasmos musculares y periodos alternos de dificultad respiratoria.
Conclusiones: Nuestro caso ilustra al SPR esporádico en la tercera edad, con una respuesta subóptima al tratamiento con inmunomoduladores. Es importante en este grupo de edad continuar con la búqueda de neoplasias anualmente, pues con cierta frecuencia el síndrome neurológico paraneoplásico precede a la presencia de neoplasia en años.


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